8CCZ
Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | polymer | 282 | 31340.1 | 2 | UniProt (Q9NTG7) Pfam (PF02146) | Homo sapiens (human) | hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3 |
| 2 | C, D (C, D) | Protein Tat | polymer | 23 | 2741.3 | 2 | UniProt (P12506) Pfam (PF00539) | Human immunodeficiency virus 1 | Transactivating regulatory protein |
| 3 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 472 | Chemie (HOH) |
Sequence modifications
C, D: 37 - 59 (UniProt: P12506)
| PDB | External Database | Details |
|---|---|---|
| Ala 37 | Cys 37 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68162.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 68293.5 |
