8CCZ

Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	polymer	282	31340.1	2	UniProt (Q9NTG7) Pfam (PF02146) In PDB	Homo sapiens (human)	hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3
2	C, D	Protein Tat	polymer	23	2741.3	2	UniProt (P12506) Pfam (PF00539) In PDB	Human immunodeficiency virus 1	Transactivating regulatory protein
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4		water	water		18.0	472	Chemie (HOH)

Sequence modifications

C, D: 37 - 59 (UniProt: P12506)

PDB	External Database	Details
Ala 37	Cys 37	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	68162.7
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	68293.5

*Water molecules are not included.