8CCZ
Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0001070 | molecular_function | RNA-binding transcription regulator activity |
| C | 0042025 | cellular_component | host cell nucleus |
| C | 0050434 | biological_process | positive regulation of viral transcription |
| D | 0001070 | molecular_function | RNA-binding transcription regulator activity |
| D | 0042025 | cellular_component | host cell nucleus |
| D | 0050434 | biological_process | positive regulation of viral transcription |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04079 |
| Chain | Residue | Details |
| C | ALA37 | |
| D | ALA37 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by host EP300 and GCN5L2 => ECO:0000255|HAMAP-Rule:MF_04079 |
| Chain | Residue | Details |
| C | LYS50 | |
| C | LYS51 | |
| D | LYS50 | |
| D | LYS51 | |
| B | GLY145 | |
| B | GLN228 | |
| B | GLY319 | |
| B | ASN344 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Asymmetric dimethylarginine; by host PRMT6 => ECO:0000255|HAMAP-Rule:MF_04079 |
| Chain | Residue | Details |
| C | ARG52 | |
| C | ARG53 | |
| D | ARG52 | |
| D | ARG53 | |
| B | CYS256 | |
| B | CYS259 | |
| B | CYS280 | |
| B | CYS283 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104 |
| Chain | Residue | Details |
| A | LYS122 | |
| B | LYS122 |
