8CBQ
structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
| 2 | C, G | Histone H2A | polymer | 129 | 13978.2 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) In PDB | Xenopus laevis (African clawed frog) | |
| 3 | D, H | Histone H2B 1.1 | polymer | 122 | 13524.8 | 2 | UniProt (P02281) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
| 4 | I | WIDOM 601 DNA | polymer | 165 | 50699.3 | 1 | synthetic construct | ||
| 5 | J | WIDOM 601 DNA | polymer | 165 | 51170.6 | 1 | synthetic construct | ||
| 6 | K | PC4 and SFRS1-interacting protein | polymer | 530 | 60224.5 | 1 | UniProt (O75475) Pfam (PF00855) Pfam (PF11467) In PDB | Homo sapiens (human) | CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Lens epithelium-derived growth factor,Transcriptional coactivator p75/p52 |
| 7 | A, E | Histone H3 | polymer | 135 | 15332.0 | 2 | UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P84233) In PDB | Xenopus laevis (African clawed frog) |
Sequence modifications
D, H: 1 - 122 (UniProt: P02281)
A, E: 1 - 135 (UniProt: A0A310TTQ1)
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Ser 33 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Cys 111 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 270290.8 | |
| All* | Total formula weight | 270290.8 |
