8CBM
Structure of human mitochondrial CCA-adding enzyme in complex with mitochondrial pre-tRNA-Ile
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | 3-hydroxyacyl-CoA dehydrogenase type-2 | polymer | 261 | 26947.0 | 4 | UniProt (Q99714) Pfam (PF00106) In PDB | Homo sapiens (human) | 17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH |
| 2 | E | CCA tRNA nucleotidyltransferase 1, mitochondrial | polymer | 393 | 44989.3 | 1 | UniProt (Q96Q11) Pfam (PF01743) Pfam (PF12627) In PDB | Homo sapiens (human) | Mitochondrial tRNA nucleotidyl transferase,CCA-adding,mt CCA-adding enzyme,mt tRNA CCA-diphosphorylase,mt tRNA CCA-pyrophosphorylase,mt tRNA adenylyltransferase |
| 3 | F | tRNA methyltransferase 10 homolog C | polymer | 408 | 48007.8 | 1 | UniProt (Q7L0Y3) Pfam (PF01746) In PDB | Homo sapiens (human) | HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase |
| 4 | T | Mitochondrial Precursor tRNA-Ile(0,0) | polymer | 69 | 22138.2 | 1 | Homo sapiens (Human) | ||
| 5 | A, B, C, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
| 6 | E | CYTIDINE-5'-DIPHOSPHATE | non-polymer | 403.2 | 1 | Chemie (CDP) | |||
| 7 | F | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 8 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
F: 40 - 403 (UniProt: Q7L0Y3)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | initiating methionine |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Val 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Leu 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Thr 32 | - | expression tag |
| Glu 33 | - | expression tag |
| Asn 34 | - | expression tag |
| Leu 35 | - | expression tag |
| Tyr 36 | - | expression tag |
| Phe 37 | - | expression tag |
| Gln 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Ala 404 | - | expression tag |
| Glu 405 | - | expression tag |
| Asn 406 | - | expression tag |
| Leu 407 | - | expression tag |
| Tyr 408 | - | expression tag |
| Phe 409 | - | expression tag |
| Gln 410 | - | expression tag |
| Ser 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| Asp 418 | - | expression tag |
| Tyr 419 | - | expression tag |
| Lys 420 | - | expression tag |
| Asp 421 | - | expression tag |
| Asp 422 | - | expression tag |
| Asp 423 | - | expression tag |
| Asp 424 | - | expression tag |
| Lys 425 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 222923.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3441.3 | |
| All* | Total formula weight | 226364.6 |
