8CA5
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (t) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | polymer | 168 | 19658.9 | 1 | UniProt (Q59J78) Pfam (PF05071) | Mus musculus (house mouse) | Mimitin,Myc-induced mitochondrial protein,MMTN,NDUFA12-like protein |
| 2 | B (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13251.8 | 1 | UniProt (P03899) Pfam (PF00507) | Mus musculus (house mouse) | NADH dehydrogenase subunit 3 |
| 3 | C (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 224 | 24715.9 | 1 | UniProt (Q9DC70) Pfam (PF01058) | Mus musculus (house mouse) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 4 | D (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 263 | 30191.3 | 1 | UniProt (Q9DCT2) Pfam (PF00329) | Mus musculus (house mouse) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 5 | E (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52720.6 | 1 | UniProt (Q91WD5) Pfam (PF00346) | Mus musculus (house mouse) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 6 | F (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 248 | 27318.3 | 1 | UniProt (Q9D6J6) Pfam (PF01257) | Mus musculus (house mouse) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 7 | G (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50904.2 | 1 | UniProt (Q91YT0) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Mus musculus (house mouse) | Complex I-51kD,CI-51kD,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 8 | H (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79866.7 | 1 | UniProt (Q91VD9) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF13510) | Mus musculus (house mouse) | Complex I-75kD,CI-75kD |
| 9 | I (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 36105.0 | 1 | UniProt (P03888) Pfam (PF00146) | Mus musculus (house mouse) | NADH dehydrogenase subunit 1 |
| 10 | J (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 24068.4 | 1 | UniProt (Q8K3J1) Pfam (PF12838) | Mus musculus (house mouse) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 11 | K (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 172 | 18656.1 | 1 | UniProt (P03925) Pfam (PF00499) | Mus musculus (house mouse) | NADH dehydrogenase subunit 6 |
| 12 | L (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10637.6 | 1 | UniProt (P03903) Pfam (PF00420) | Mus musculus (house mouse) | NADH dehydrogenase subunit 4L |
| 13 | M (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 607 | 68547.3 | 1 | UniProt (P03921) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Mus musculus (house mouse) | NADH dehydrogenase subunit 5 |
| 14 | N (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51943.5 | 1 | UniProt (P03911) Pfam (PF01059) Pfam (PF00361) | Mus musculus (house mouse) | NADH dehydrogenase subunit 4 |
| 15 | O (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 345 | 38800.2 | 1 | UniProt (P03893) Pfam (PF00361) Pfam (PF06444) | Mus musculus (house mouse) | NADH dehydrogenase subunit 2 |
| 16 | P (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 355 | 40657.4 | 1 | UniProt (Q99LC3) Pfam (PF01712) | Mus musculus (house mouse) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 17 | Q (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42588.1 | 1 | UniProt (Q9DC69) Pfam (PF05368) | Mus musculus (house mouse) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 18 | R (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 10932.7 | 1 | UniProt (Q9CQ75) Pfam (PF05047) | Mus musculus (house mouse) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 19 | S, T (T, U) | Acyl carrier protein, mitochondrial | polymer | 156 | 17390.3 | 2 | UniProt (Q9CR21) Pfam (PF00550) | Mus musculus (house mouse) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 20 | U (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13380.7 | 1 | UniProt (Q9CPP6) Pfam (PF04716) | Mus musculus (house mouse) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 21 | V (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 131 | 15311.9 | 1 | UniProt (Q9CQZ5) Pfam (PF13233) | Mus musculus (house mouse) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 22 | W (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20025.1 | 1 | UniProt (Q9DCJ5) Pfam (PF06747) | Mus musculus (house mouse) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 23 | X (Y) | MCG5603 | polymer | 143 | 15130.4 | 1 | UniProt (G5E814) Pfam (PF02466) | Mus musculus (house mouse) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 |
| 24 | Y (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16881.6 | 1 | UniProt (Q9ERS2) Pfam (PF06212) | Mus musculus (house mouse) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 25 | Z (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8149.5 | 1 | UniProt (O35683) Pfam (PF15879) | Mus musculus (house mouse) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 26 | AA (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9338.9 | 1 | UniProt (Q9CQ91) Pfam (PF14987) | Mus musculus (house mouse) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 27 | BA (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8636.0 | 1 | UniProt (Q9CQY9) Pfam (PF15088) | Mus musculus (house mouse) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 28 | CA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14185.7 | 1 | UniProt (Q9CQ54) Pfam (PF06374) | Mus musculus (house mouse) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 29 | DA (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12675.8 | 1 | UniProt (Q99LY9) Pfam (PF10200) | Mus musculus (house mouse) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 30 | EA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6965.1 | 1 | UniProt (P0DN34) Pfam (PF08040) | Mus musculus (house mouse) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 31 | FA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 151 | 17463.7 | 1 | UniProt (O09111) Pfam (PF10183) | Mus musculus (house mouse) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 15.6,p15.6 |
| 32 | GA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21742.2 | 1 | UniProt (Q9CQH3) Pfam (PF09781) | Mus musculus (house mouse) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 33 | HA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15540.1 | 1 | UniProt (Q3UIU2) Pfam (PF09782) | Mus musculus (house mouse) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 34 | IA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11982.4 | 1 | UniProt (Q9CPU2) Pfam (PF14813) | Mus musculus (house mouse) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 35 | JA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 104 | 11714.2 | 1 | UniProt (Q9CQZ6) Pfam (PF08122) | Mus musculus (house mouse) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 36 | KA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21903.8 | 1 | UniProt (Q9D6J5) Pfam (PF05821) | Mus musculus (house mouse) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 37 | LA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15105.3 | 1 | UniProt (Q9CQC7) Pfam (PF07225) | Mus musculus (house mouse) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 38 | MA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 22020.1 | 1 | UniProt (Q9CQJ8) Pfam (PF05347) | Mus musculus (house mouse) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 39 | NA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16360.8 | 1 | UniProt (Q9CR61) Pfam (PF05676) | Mus musculus (house mouse) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 40 | OA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21054.8 | 1 | UniProt (Q9DCS9) Pfam (PF10249) | Mus musculus (house mouse) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 41 | PA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12595.6 | 1 | UniProt (Q9Z1P6) Pfam (PF07347) | Mus musculus (house mouse) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 42 | QA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 104 | 11833.5 | 1 | UniProt (Q8BK30) Pfam (PF15880) | Mus musculus (house mouse) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 43 | CB, DB, RA, VA, XA... (I, B, F, G) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 44 | EB, SA (J, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) PubChem (65146) PubChem (94190) PubChem (10417837) | |||
| 45 | BB, FB, GB, IB, LB... (H, K, L, M, Y...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 7 | Chemie (3PE) | |||
| 46 | UA, ZA (E, G) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 47 | WA (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (8965) PubChem (23585816) PubChem (643976) PubChem (51435500) PubChem (51435503) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 48 | AB (H) | Ubiquinone-9 | non-polymer | 795.2 | 1 | Chemie (UQ9) PubChem (99490) PubChem (97038294) PubChem (97038295) PubChem (5280473) PubChem (97038296) PubChem (125181414) PubChem (137350099) | |||
| 49 | HB, MB, NB, TB, UB... (L, M, N, d, i) | CARDIOLIPIN | non-polymer | 1464.0 | 6 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 50 | JB, KB (L) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 2 | Chemie (LMT) | |||
| 51 | OB (O) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 52 | PB (P) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 53 | QB, RB (T, U) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) PubChem (71777704) PubChem (137349255) PubChem (163183360) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 43 |
| Total formula weight | 1016341.9 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 22773.3 | |
| All* | Total formula weight | 1039115.2 |
