8C7Z
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2308
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Activin receptor type I | polymer | 301 | 34537.6 | 1 | UniProt (Q04771) Pfam (PF00069) In PDB | Homo sapiens (human) | |
| 2 | A | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 3 | A | 9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1]benzoxepino[5,4-c]pyridine | non-polymer | 447.5 | 1 | Chemie (TZX) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34537.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1628.6 | |
| All* | Total formula weight | 36166.3 |
