8C5L

NR2F6 ligand binding domain in complex with NSD1 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltose/maltodextrin-binding periplasmic protein,Nuclear receptor subfamily 2 group F member 6	polymer	568	61867.6	2	UniProt (P0AEX9) UniProt (P10588) Pfam (PF01547) Pfam (PF00104)	Escherichia coli K-12	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,V-erbA-related protein 2,EAR-2
2	C, D (C, D)	Histone-lysine N-methyltransferase, H3 lysine-36 specific	polymer	19	2308.7	2	UniProt (Q96L73)	Homo sapiens	Androgen receptor coactivator 267 kDa protein,Androgen receptor-associated protein of 267 kDa,H3-K36-HMTase,Lysine N-methyltransferase 3B,Nuclear receptor-binding SET domain-containing protein 1,NR-binding SET domain-containing protein
3	E, F (F, G)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)
4	G, H (A, B)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B: 2 - 367 (UniProt: P0AEX9)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 83	Asp 108	engineered mutation
Ala 84	Lys 109	engineered mutation
Ala 173	Glu 198	engineered mutation
Ala 174	Asn 199	engineered mutation
Ala 240	Lys 265	engineered mutation
Ala 360	Glu 385	engineered mutation
Ala 363	Lys 388	engineered mutation
Ala 364	Asp 389	engineered mutation
Asn 368	-	linker
Ala 369	-	linker
Ala 370	-	linker
Ala 371	-	linker
Glu 372	-	linker
Phe 373	-	linker

A, B: 374 - 568 (UniProt: P10588)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128352.6
Branched	Number of molecules	2
	Total formula weight	684.6
All*	Total formula weight	129037.2

*Water molecules are not included.