8C3R
Crystal structure of DYRK1A in complex with gossypin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 370 | 43180.6 | 2 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB |
| 2 | C, E (A, B) | Gossypin | non-polymer | 480.4 | 2 | Chemie (R7O) | |||
| 3 | D, F, G, H (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 420 | Chemie (HOH) |
Sequence modifications
A, B: 126 - 489 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| His 490 | - | expression tag |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86361.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1196.9 | |
| All* | Total formula weight | 87558.1 |
