8C1S

Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor 2	polymer	891	99981.0	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	E, F, G, H (E, F, G, H)	Voltage-dependent calcium channel gamma-2 subunit	polymer	322	35807.6	4	UniProt (Q71RJ2) Pfam (PF00822)	Rattus norvegicus (Norway rat)	Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
3	I, K, O, Q, T... (A, B, C, D, F...)	PALMITIC ACID	non-polymer		256.4	6	Chemie (PLM)
4	J, L, N, P (A, B, C)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	4	Chemie (OLC)
5	M, R, S, V (B, D, E, G)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	4	Chemie (POV)
6	AA, BA, W, X, Y... (F, G, A, B, C...)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A, B, C, D: -28 - 862 (UniProt: P19491)

PDB	External Database	Details
Asp -7	-	insertion
Tyr -6	-	insertion
Lys -5	-	insertion
Asp -4	-	insertion
Asp -3	-	insertion
Asp -2	-	insertion
Asp -1	-	insertion
Lys 0	-	insertion
Arg 586	Gln 607	conflict
Arg 743	Gly 764	conflict
Ser 754	Asn 775	conflict
Val 758	Leu 779	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	543154.3
Non-Polymers*	Number of molecules	14
	Total formula weight	6005.0
All*	Total formula weight	549159.4

*Water molecules are not included.