8C1P

Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor 1 flip isoform	polymer	915	102661.9	4	UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1
2	E, F, G, H (E, F, G, H)	Voltage-dependent calcium channel gamma-3 subunit	polymer	314	35435.3	4	UniProt (Q8VHX0) Pfam (PF00822)	Rattus norvegicus (Norway rat)	Neuronal voltage-gated calcium channel gamma-3 subunit,Transmembrane AMPAR regulatory protein gamma-3,TARP gamma-3
3	I, M, R, V (A, B, C, D)	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ)
4	J, N, P, S, W... (A, B, C, D)	PALMITIC ACID	non-polymer		256.4	6	Chemie (PLM)
5	K, O, T, X (A, B, C, D)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	4	Chemie (OLC)
6	L, Q, U, Z (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
7	AA, BA (E, G)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	2	Chemie (POV)
8	CA, DA, EA, FA, GA... (A, B, C, D, E...)	water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B, C, D: -25 - 889 (UniProt: P19490)

PDB	External Database	Details
Asp -6	-	insertion
Tyr -5	-	insertion
Lys -4	-	insertion
Asp -3	-	insertion
Asp -2	-	insertion
Asp -1	-	insertion
Asp 0	-	insertion
Lys 1	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	552389.0
Non-Polymers*	Number of molecules	20
	Total formula weight	6632.9
All*	Total formula weight	559021.9

*Water molecules are not included.