8C1C

Structure of IgE bound to the ectodomain of FceRIa

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H, X	Immunoglobulin heavy constant epsilon	polymer	426	46831.6	2	UniProt (P01854) Pfam (PF07654) In PDB	Homo sapiens (human)	Ig epsilon chain C region,Ig epsilon chain C region ND
2	L, Y	Immunoglobulin kappa constant	polymer	107	11764.0	2	UniProt (P01834) Pfam (PF07654) In PDB	Homo sapiens (human)	Ig kappa chain C region,Ig kappa chain C region AG,Ig kappa chain C region CUM,Ig kappa chain C region EU,Ig kappa chain C region OU,Ig kappa chain C region ROY,Ig kappa chain C region TI
3	R	High affinity immunoglobulin epsilon receptor subunit alpha	polymer	171	19880.1	1	UniProt (P12319) Pfam (PF13927) Pfam (PF13895) In PDB	Homo sapiens (human)	Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha
4	A, G	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
5	B, C	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G21381MC)
6	D, E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
7	R	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

H, X: 117 - 539 (UniProt: P01854)

PDB	External Database	Details
Ser 540	-	expression tag
Val 541	-	expression tag
Ala 542	-	expression tag

L, Y: 111 - 217 (UniProt: P01834)

PDB	External Database	Details
Gly 114	Ala 4	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	137071.3
Branched	Number of molecules	7
	Total formula weight	4916.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	142430.2

*Water molecules are not included.