8C1C
Structure of IgE bound to the ectodomain of FceRIa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (H, X) | Immunoglobulin heavy constant epsilon | polymer | 426 | 46831.6 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | Ig epsilon chain C region,Ig epsilon chain C region ND |
| 2 | B, E (L, Y) | Immunoglobulin kappa constant | polymer | 107 | 11764.0 | 2 | UniProt (P01834) Pfam (PF07654) | Homo sapiens (human) | Ig kappa chain C region,Ig kappa chain C region AG,Ig kappa chain C region CUM,Ig kappa chain C region EU,Ig kappa chain C region OU,Ig kappa chain C region ROY,Ig kappa chain C region TI |
| 3 | C (R) | High affinity immunoglobulin epsilon receptor subunit alpha | polymer | 171 | 19880.1 | 1 | UniProt (P12319) Pfam (PF13927) Pfam (PF13895) | Homo sapiens (human) | Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha |
| 4 | F, L (A, G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 5 | G, H (B, C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G21381MC) | |||
| 6 | I, J, K (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 7 | M, N (R) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
H, X: 117 - 539 (UniProt: P01854)
L, Y: 111 - 217 (UniProt: P01834)
| PDB | External Database | Details |
|---|---|---|
| Ser 540 | - | expression tag |
| Val 541 | - | expression tag |
| Ala 542 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 114 | Ala 4 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 137071.3 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4916.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 142430.2 |
