8C1C

Structure of IgE bound to the ectodomain of FceRIa

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016020	cellular_component	membrane
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
Y	0002250	biological_process	adaptive immune response
Y	0002376	biological_process	immune system process
Y	0003823	molecular_function	antigen binding
Y	0005576	cellular_component	extracellular region
Y	0005615	cellular_component	extracellular space
Y	0005886	cellular_component	plasma membrane
Y	0006955	biological_process	immune response
Y	0016020	cellular_component	membrane
Y	0016064	biological_process	immunoglobulin mediated immune response
Y	0019814	cellular_component	immunoglobulin complex
Y	0050853	biological_process	B cell receptor signaling pathway
Y	0070062	cellular_component	extracellular exosome
Y	0071735	cellular_component	IgG immunoglobulin complex
Y	0071738	cellular_component	IgD immunoglobulin complex
Y	0071742	cellular_component	IgE immunoglobulin complex
Y	0071745	cellular_component	IgA immunoglobulin complex
Y	0071753	cellular_component	IgM immunoglobulin complex
Y	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCRVAH

Chain	Residue	Details
H	PHE199-HIS205
H	TYR413-HIS419
H	PHE519-HIS525
L	TYR195-HIS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	194
Details	Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	196
Details	Domain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	208
Details	Domain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	198
Details	Domain: {"description":"Ig-like 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10917520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	194
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Domain: {"description":"Ig-like 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	82
Details	Domain: {"description":"Ig-like 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10917520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11531339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9875849","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11531339","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---