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8BWP

Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with methotrexate)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
ATP-binding cassette sub-family C member 4polymer1325149693.91UniProt (O15439)
Pfam (PF00664)
Pfam (PF00005)
Homo sapiens (human)MRP/cMOAT-related ABC transporter,Multi-specific organic anion transporter B,MOAT-B,Multidrug resistance-associated protein 4
2B
(A)
METHOTREXATEnon-polymer454.41Chemie (MTX)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight149693.9
Non-Polymers*Number of molecules1
Total formula weight454.4
All*Total formula weight150148.4
*Water molecules are not included.

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PDB entries from 2025-07-02

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