8BW0

Structure of CEACAM5 A3-B3 domain in Complex with Tusamitamab Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Tusamitamab Fab heavy Chain	polymer	234	24833.7	1		Mus sp.
2	B (L)	Tusamitamab Light Chain	polymer	214	23497.1	1		Mus sp.
3	C (C)	Carcinoembryonic antigen-related cell adhesion molecule 5	polymer	193	20883.0	1	UniProt (P06731) Pfam (PF13927)	Homo sapiens (human)	Carcinoembryonic antigen,CEA,Meconium antigen 100
4	D, F (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	E (B)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	1	In PDB GlyTouCan (G82348BZ)
6	G, H, I (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

C: 499 - 685 (UniProt: P06731)

PDB	External Database	Details
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
His 689	-	expression tag
His 690	-	expression tag
His 691	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	69213.8
Branched	Number of molecules	3
	Total formula weight	1905.8
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	71783.2

*Water molecules are not included.