8BUR
Structure of DDB1 bound to DS50-engaged CDK12-cyclin K
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, G | DNA damage-binding protein 1 | polymer | 840 | 93675.4 | 3 | UniProt (Q16531) In PDB | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
2 | E, B, H | Cyclin-dependent kinase 12 | polymer | 344 | 40143.3 | 3 | UniProt (Q9NYV4) In PDB | Homo sapiens (human) | Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12 |
3 | F, C, I | Cyclin-K | polymer | 271 | 31700.5 | 3 | UniProt (O75909) In PDB | Homo sapiens (human) | |
4 | C, G, I, D, F... | SULFATE ION | non-polymer | 96.1 | 24 | Chemie (SO4) | |||
5 | H, E, B | ~{N}-[2-(2-methoxyphenyl)ethyl]-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]ethanamide | non-polymer | 550.7 | 3 | Chemie (RQU) |
Sequence modifications
D, A, G: 1 - 699 (UniProt: Q16531)
D, A, G: 709 - 1140 (UniProt: Q16531)
E, B, H: 712 - 1051 (UniProt: Q9NYV4)
F, C, I: 1 - 267 (UniProt: O75909)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 700 | - | linker |
Asn 701 | - | linker |
Gly 702 | - | linker |
Asn 703 | - | linker |
Ser 704 | - | linker |
Gly 705 | - | linker |
Glu 706 | - | linker |
Ile 707 | - | linker |
Gln 708 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 709 | - | expression tag |
Gly 710 | - | expression tag |
Gly 711 | - | expression tag |
Arg 965 | Lys 965 | engineered mutation |
Gln 1052 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 496557.7 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 3957.5 | |
All* | Total formula weight | 500515.2 |