8BU6

Structure of DDB1 bound to DS55-engaged CDK12-cyclin K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, D, A	DNA damage-binding protein 1	polymer	840	93675.4	3	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	H, E, B	Cyclin-dependent kinase 12	polymer	344	40143.3	3	UniProt (Q9NYV4) Pfam (PF00069) In PDB	Homo sapiens (human)	Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12
3	I, F, C	Cyclin-K	polymer	271	31700.5	3	UniProt (O75909) Pfam (PF00134) Pfam (PF21797) In PDB	Homo sapiens (human)
4	G, I, F, A, C	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	H, E, B	~{N}-(1~{H}-benzimidazol-2-ylmethyl)-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine	non-polymer		430.5	3	Chemie (RQE)

Sequence modifications

G, D, A: 1 - 699 (UniProt: Q16531)

G, D, A: 709 - 1140 (UniProt: Q16531)

H, E, B: 712 - 1051 (UniProt: Q9NYV4)

I, F, C: 1 - 267 (UniProt: O75909)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.