8BS6

Crystal structure of YTHDF3 disulfide mutant (closed conformation)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	YTH domain-containing family protein 3	polymer	216	25507.8	1	UniProt (Q7Z739) Pfam (PF04146)	Homo sapiens (human)	DF3
2	B (A)	water	water		18.0	292	Chemie (HOH)

Sequence modifications

A: 388 - 585 (UniProt: Q7Z739)

PDB	External Database	Details
Met 370	-	initiating methionine
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
Ser 377	-	expression tag
Ser 378	-	expression tag
Gly 379	-	expression tag
Arg 380	-	expression tag
Glu 381	-	expression tag
Asn 382	-	expression tag
Leu 383	-	expression tag
Tyr 384	-	expression tag
Phe 385	-	expression tag
Gln 386	-	expression tag
Gly 387	-	expression tag
Cys 425	Ser 425	engineered mutation
Cys 493	Ser 493	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25507.8
All*	Total formula weight	25507.8

*Water molecules are not included.