8BS4

Crystal structure of YTHDF1 YTH domain dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	YTH domain-containing family protein 1	polymer	213	25007.1	2	UniProt (Q9BYJ9) Pfam (PF04146)	Homo sapiens (human)	DF1,Dermatomyositis associated with cancer putative autoantigen 1,DACA-1
2	C (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
3	D (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E, F (A, B)	water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B: 365 - 559 (UniProt: Q9BYJ9)

PDB	External Database	Details
Met 347	-	initiating methionine
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
Ser 354	-	expression tag
Ser 355	-	expression tag
Gly 356	-	expression tag
Arg 357	-	expression tag
Glu 358	-	expression tag
Asn 359	-	expression tag
Leu 360	-	expression tag
Tyr 361	-	expression tag
Phe 362	-	expression tag
Gln 363	-	expression tag
Gly 364	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50014.2
Non-Polymers*	Number of molecules	2
	Total formula weight	151.1
All*	Total formula weight	50165.3

*Water molecules are not included.