8BR5

Discovery of IRAK4 Inhibitor 41

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Interleukin-1 receptor-associated kinase 4	polymer	299	33770.0	4	UniProt (Q9NWZ3) Pfam (PF07714)	Homo sapiens (human)	IRAK-4,Renal carcinoma antigen NY-REN-64
2	E, F, G, H (AAA, BBB, CCC, DDD)	~{N}-[2,3-dimethyl-6-(1~{H}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	non-polymer		400.4	4	Chemie (R73)
3	I, J, K, L (AAA, BBB, CCC, DDD)	water	water		18.0	145	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	135079.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1601.4
All*	Total formula weight	136681.4

*Water molecules are not included.