8BPC
Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Paired amphipathic helix protein Sin3b | polymer | 1130 | 129547.1 | 1 | UniProt (O75182) Pfam (PF02671) Pfam (PF08295) Pfam (PF16879) | Homo sapiens (human) | Histone deacetylase complex subunit Sin3b,Transcriptional corepressor Sin3b |
| 2 | B (B) | Histone deacetylase 2 | polymer | 488 | 55443.2 | 1 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (human) | HD2,Protein deacylase HDAC2 |
| 3 | C (C) | PHD finger protein 12 | polymer | 364 | 41257.1 | 1 | UniProt (Q96QT6) Pfam (PF00628) Pfam (PF16737) | Homo sapiens (human) | PHD factor 1,Pf1 |
| 4 | D (B) | OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE | non-polymer | 264.3 | 1 | Chemie (SHH) | |||
| 5 | E, H, I (B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | F, G (B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 226247.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 540.7 | |
| All* | Total formula weight | 226788.1 |
