8BP2
2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (BBB, DDD) | DNA gyrase subunit B | polymer | 189 | 21274.2 | 2 | UniProt (P66937) Pfam (PF01751) Pfam (PF00986) | Staphylococcus aureus | |
| 2 | B, D (AAA, CCC) | DNA gyrase subunit A | polymer | 490 | 55537.3 | 2 | UniProt (Q99XG5) Pfam (PF00521) | Staphylococcus aureus | |
| 3 | E, F, G, H (EEE, EbE, FFF, FbF) | DNA (20-MER) | polymer | 20 | 6151.0 | 4 | synthetic construct | ||
| 4 | I, K, M, N, O... (BBB, AAA, CCC, FbF) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 5 | J, P, Q (BBB, DDD, CCC) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 6 | L (AAA) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | R (CCC) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
| 8 | T, V (EbE, FbF) | Zoliflodacin | non-polymer | 487.4 | 2 | Chemie (R8U) | |||
| 9 | AA, BA, CA, DA, W... (EEE, EbE, FFF, FbF, BBB...) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
BBB, DDD: 417 - null (UniProt: P66937)
BBB, DDD: 580 - 639 (UniProt: P66937)
| PDB | External Database | Details |
|---|---|---|
| - | Leu 544 | deletion |
| - | Tyr 545 | deletion |
| - | Lys 546 | deletion |
| - | Leu 547 | deletion |
| - | Thr 548 | deletion |
| - | Gln 549 | deletion |
| - | Gly 550 | deletion |
| - | Lys 551 | deletion |
| - | Gln 552 | deletion |
| - | Lys 553 | deletion |
| - | Tyr 554 | deletion |
| - | Tyr 555 | deletion |
| - | Val 556 | deletion |
| - | Tyr 557 | deletion |
| - | Asn 558 | deletion |
| - | Asp 559 | deletion |
| - | Arg 560 | deletion |
| - | Glu 561 | deletion |
| - | Leu 562 | deletion |
| - | Asp 563 | deletion |
| - | Lys 564 | deletion |
| - | Leu 565 | deletion |
| - | Lys 566 | deletion |
| - | Ser 567 | deletion |
| - | Glu 568 | deletion |
| - | Leu 569 | deletion |
| - | Asn 570 | deletion |
| - | Pro 571 | deletion |
| - | Thr 572 | deletion |
| - | Pro 573 | deletion |
| - | Lys 574 | deletion |
| - | Trp 575 | deletion |
| - | Ser 576 | deletion |
| - | Ile 577 | deletion |
| - | Ala 578 | deletion |
| - | Arg 579 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Thr 544 | - | linker |
| Gly 545 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 178226.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2016.6 | |
| All* | Total formula weight | 180243.4 |
