8BLB
Human serotonin 5-HT3A receptor in complex with vortioxetine (nanodiscs, ECD, active/distorted conformation)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | 5-hydroxytryptamine receptor 3A | polymer | 450 | 52172.3 | 5 | UniProt (P46098) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | 5-HT3-A,5-HT3A,5-hydroxytryptamine receptor 3,5-HT-3,5-HT3R,Serotonin receptor 3A,Serotonin-gated ion channel receptor |
| 2 | F, G, H, I, J... (F, G, H, I, J...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 10 | In PDB GlyTouCan (G42666HT) | |||
| 3 | P, R, T, V, X (A, B, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 4 | Q, S, U, W, Y (A, B, C, D, E) | Vortioxetine | non-polymer | 298.4 | 5 | Chemie (VTX) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 260861.6 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 4244.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2598.3 | |
| All* | Total formula weight | 267703.9 |
