8BLB
Human serotonin 5-HT3A receptor in complex with vortioxetine (nanodiscs, ECD, active/distorted conformation)
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC |
| Chain | Residue | Details |
| A | CYS157-CYS171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO242-PRO268 | |
| B | PRO242-PRO268 | |
| C | PRO242-PRO268 | |
| D | PRO242-PRO268 | |
| E | PRO242-PRO268 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 685 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P23979 |
| Chain | Residue | Details |
| A | ASN269-ARG273 | |
| E | GLU322-HIS455 | |
| A | GLU322-HIS455 | |
| B | ASN269-ARG273 | |
| B | GLU322-HIS455 | |
| C | ASN269-ARG273 | |
| C | GLU322-HIS455 | |
| D | ASN269-ARG273 | |
| D | GLU322-HIS455 | |
| E | ASN269-ARG273 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL274-SER292 | |
| B | VAL274-SER292 | |
| C | VAL274-SER292 | |
| D | VAL274-SER292 | |
| E | VAL274-SER292 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 55 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P23979 |
| Chain | Residue | Details |
| A | ASP293-THR302 | |
| E | GLN476-ALA478 | |
| A | GLN476-ALA478 | |
| B | ASP293-THR302 | |
| B | GLN476-ALA478 | |
| C | ASP293-THR302 | |
| C | GLN476-ALA478 | |
| D | ASP293-THR302 | |
| D | GLN476-ALA478 | |
| E | ASP293-THR302 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 90 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO303-ALA321 | |
| B | PRO303-ALA321 | |
| C | PRO303-ALA321 | |
| D | PRO303-ALA321 | |
| E | PRO303-ALA321 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 95 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE456-TRP475 | |
| B | ILE456-TRP475 | |
| C | ILE456-TRP475 | |
| D | ILE456-TRP475 | |
| E | ILE456-TRP475 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN104 | |
| D | ASN104 | |
| D | ASN170 | |
| D | ASN186 | |
| E | ASN104 | |
| E | ASN170 | |
| E | ASN186 | |
| A | ASN170 | |
| A | ASN186 | |
| B | ASN104 | |
| B | ASN170 | |
| B | ASN186 | |
| C | ASN104 | |
| C | ASN170 | |
| C | ASN186 |
