8BI0

ABCG2 turnover-2 state with tariquidar bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Broad substrate specificity ATP-binding cassette transporter ABCG2	polymer	665	73526.9	2	UniProt (Q9UNQ0) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061) In PDB	Homo sapiens (human)	ATP-binding cassette sub-family G member 2,Breast cancer resistance protein,CDw338,Mitoxantrone resistance-associated protein,Placenta-specific ATP-binding cassette transporter,Urate exporter
2	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
3	A, B	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR)
4	A, B	DIUNDECYL PHOSPHATIDYL CHOLINE	non-polymer		622.8	2	Chemie (PLC)
5	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	B	tariquidar	non-polymer		646.7	1	Chemie (R1H)

Sequence modifications

A, B: 2 - 655 (UniProt: Q9UNQ0)

PDB	External Database	Details
Met -9	-	initiating methionine
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	147053.9
Non-Polymers*	Number of molecules	11
	Total formula weight	4502.0
All*	Total formula weight	151555.9

*Water molecules are not included.