8BHG
GABA-A receptor a5 heteromer - a5V2 - Bretazenil
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, D, E | Gamma-aminobutyric acid receptor subunit alpha-5 | polymer | 350 | 40148.9 | 4 | UniProt (P31644) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit alpha-5 |
2 | B | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 379 | 43751.9 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit gamma-2 |
3 | A, B, D | Bretazenil | non-polymer | 418.3 | 5 | Chemie (QMU) | |||
4 | A, B, C, D, E | DECYL-BETA-D-MALTOPYRANOSIDE | non-polymer | 482.6 | 5 | Chemie (DMU) | |||
5 | A, B, C | NITRATE ION | non-polymer | 62.0 | 3 | Chemie (NO3) | |||
6 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
7 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, C, D, E: 1 - 457 (UniProt: P31644)
B: 1 - 486 (UniProt: P18507)
PDB | External Database | Details |
---|---|---|
Met 48 | Ile 79 | engineered mutation |
Asn 51 | Thr 82 | engineered mutation |
Ile 67 | Val 98 | engineered mutation |
Ala 70 | Arg 101 | engineered mutation |
Thr 72 | Ser 103 | engineered mutation |
Asp 90 | Asn 121 | engineered mutation |
Arg 92 | Leu 123 | engineered mutation |
Val 93 | Leu 124 | engineered mutation |
Asp 95 | Ser 126 | engineered mutation |
Gln 96 | Lys 127 | engineered mutation |
Asp 107 | Gly 138 | engineered mutation |
Phe 111 | Ile 142 | engineered mutation |
Gly 114 | Asn 145 | conflict |
Met 121 | Leu 152 | engineered mutation |
Ile 124 | Leu 155 | engineered mutation |
Trp 125 | Glu 156 | engineered mutation |
Asn 126 | Asp 157 | engineered mutation |
Arg 129 | Thr 160 | engineered mutation |
Val 130 | Leu 161 | engineered mutation |
Asp 145 | Gln 176 | engineered mutation |
Glu 153 | Ala 184 | engineered mutation |
Gln 154 | His 185 | engineered mutation |
Asn 155 | Ala 186 | engineered mutation |
Ala 256 | Pro 287 | engineered mutation |
Leu 305 | Ile 336 | engineered mutation |
Phe 309 | Thr 340 | engineered mutation |
Ile 313 | Phe 344 | engineered mutation |
Ser 316 | Arg 347 | conflict |
Gln 317 | Gly 348 | conflict |
Pro 318 | Trp 349 | conflict |
- | Trp 351 | deletion |
- | Asp 352 | deletion |
- | Gly 353 | deletion |
- | Lys 354 | deletion |
- | Lys 355 | deletion |
- | Ala 356 | deletion |
- | Leu 357 | deletion |
- | Glu 358 | deletion |
- | Ala 359 | deletion |
- | Ala 360 | deletion |
- | Lys 361 | deletion |
- | Ile 362 | deletion |
- | Lys 363 | deletion |
- | Lys 364 | deletion |
- | Lys 365 | deletion |
- | Arg 366 | deletion |
- | Glu 367 | deletion |
- | Val 368 | deletion |
- | Ile 369 | deletion |
- | Leu 370 | deletion |
- | Asn 371 | deletion |
- | Lys 372 | deletion |
- | Ser 373 | deletion |
- | Thr 374 | deletion |
- | Asn 375 | deletion |
- | Ala 376 | deletion |
- | Phe 377 | deletion |
- | Thr 378 | deletion |
- | Thr 379 | deletion |
- | Gly 380 | deletion |
- | Lys 381 | deletion |
- | Met 382 | deletion |
- | Ser 383 | deletion |
- | His 384 | deletion |
- | Pro 385 | deletion |
- | Pro 386 | deletion |
- | Asn 387 | deletion |
- | Ile 388 | deletion |
- | Pro 389 | deletion |
- | Lys 390 | deletion |
- | Glu 391 | deletion |
- | Gln 392 | deletion |
- | Thr 393 | deletion |
- | Pro 394 | deletion |
- | Ala 395 | deletion |
- | Gly 396 | deletion |
- | Thr 397 | deletion |
- | Ser 398 | deletion |
- | Asn 399 | deletion |
- | Thr 400 | deletion |
- | Thr 401 | deletion |
- | Ser 402 | deletion |
- | Val 403 | deletion |
- | Ser 404 | deletion |
- | Val 405 | deletion |
- | Lys 406 | deletion |
- | Pro 407 | deletion |
- | Ser 408 | deletion |
- | Glu 409 | deletion |
- | Glu 410 | deletion |
- | Lys 411 | deletion |
- | Thr 412 | deletion |
- | Ser 413 | deletion |
- | Glu 414 | deletion |
- | Ser 415 | deletion |
- | Lys 416 | deletion |
- | Lys 417 | deletion |
- | Thr 418 | deletion |
- | Tyr 419 | deletion |
- | Asn 420 | deletion |
Arg 320 | Ser 421 | conflict |
Ala 321 | Ile 422 | conflict |
Ala 322 | Ser 423 | conflict |
Ile 441 | Val 435 | conflict |
PDB | External Database | Details |
---|---|---|
Thr 11 | Ala 50 | conflict |
Ile 233 | Met 272 | conflict |
Val 237 | Thr 276 | conflict |
Leu 242 | Ile 281 | conflict |
Ile 245 | Thr 284 | conflict |
Met 246 | Leu 285 | conflict |
Thr 247 | Ile 286 | conflict |
Ile 249 | Val 288 | conflict |
Gln 252 | Trp 291 | conflict |
Leu 257 | Ile 296 | conflict |
Arg 259 | Lys 298 | conflict |
Glu 260 | Asp 299 | conflict |
Ser 261 | Ala 300 | conflict |
Ala 263 | Pro 302 | conflict |
Val 267 | Ser 306 | conflict |
Phe 268 | Leu 307 | conflict |
Val 270 | Ile 309 | conflict |
Ile 281 | Thr 320 | conflict |
Ser 282 | Ile 321 | conflict |
Asn 285 | Lys 324 | conflict |
Ala 291 | Ser 330 | conflict |
Ala 293 | Val 332 | conflict |
Trp 298 | Leu 337 | conflict |
Ile 300 | Val 339 | conflict |
Ala 301 | Ser 340 | conflict |
Tyr 304 | Phe 343 | conflict |
Ala 305 | Ile 344 | conflict |
Ile 312 | Val 351 | conflict |
Phe 314 | Tyr 353 | conflict |
Ala 315 | Gly 354 | conflict |
Val 317 | Leu 356 | conflict |
Asn 318 | His 357 | conflict |
Thr 321 | - | insertion |
Lys 322 | Val 360 | conflict |
Gln 324 | - | insertion |
Pro 325 | - | insertion |
Ala 326 | Asn 362 | conflict |
Ala 328 | Lys 364 | conflict |
Ala 329 | Pro 365 | conflict |
Lys 330 | Ser 366 | conflict |
Ile 438 | Lys 367 | conflict |
Arg 440 | Lys 369 | conflict |
Leu 441 | Asp 370 | conflict |
Ser 442 | Lys 371 | conflict |
Arg 443 | Lys 372 | conflict |
Ile 444 | Lys 373 | conflict |
Ala 445 | Lys 374 | conflict |
Phe 446 | Asn 375 | conflict |
Phe 450 | - | insertion |
Gly 451 | Arg 379 | conflict |
Ile 452 | Met 380 | conflict |
Asn 454 | - | insertion |
Leu 455 | Ser 382 | conflict |
Val 456 | Phe 383 | conflict |
Tyr 457 | Lys 384 | conflict |
Trp 458 | Ala 385 | conflict |
Ala 459 | Pro 386 | conflict |
Tyr 461 | Ile 388 | conflict |
Leu 462 | Asp 389 | conflict |
Asn 463 | Ile 390 | conflict |
Glu 465 | - | insertion |
Gln 467 | - | insertion |
Leu 468 | - | insertion |
Lys 469 | Arg 393 | conflict |
Ala 470 | Ser 394 | conflict |
Pro 471 | Ala 395 | conflict |
Pro 473 | - | insertion |
His 474 | Ile 397 | conflict |
Gly 476 | Met 399 | conflict |
Thr 477 | Asn 400 | conflict |
Thr 478 | Asn 401 | conflict |
Glu 479 | Ala 402 | conflict |
Ser 481 | His 404 | conflict |
Gln 482 | Leu 405 | conflict |
Val 483 | Gln 406 | conflict |
Ala 484 | Glu 407 | conflict |
Pro 485 | Arg 408 | conflict |
Ala 486 | Asp 409 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 204347.4 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 6017.5 | |
All* | Total formula weight | 210364.9 |