8BE5
Crystal structure of SOS1-KRasG12V-Nanobody22-Nanobody75
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAZA) | Son of sevenless homolog 1 | polymer | 507 | 59348.8 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) | Homo sapiens (human) | SOS-1 |
| 2 | B (C) | Nanobody75 | polymer | 136 | 14658.2 | 1 | Lama glama | ||
| 3 | C (R) | Isoform 2B of GTPase KRas | polymer | 190 | 21675.3 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 4 | D (N) | Nanobody22 | polymer | 124 | 13892.5 | 1 | Lama glama | ||
| 5 | E, F, G, H (AAZA, C, R, N) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
AAZA: 564 - 1049 (UniProt: Q07889)
R: 1 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Met 543 | - | initiating methionine |
| Gly 544 | - | expression tag |
| Ser 545 | - | expression tag |
| Ser 546 | - | expression tag |
| His 547 | - | expression tag |
| His 548 | - | expression tag |
| His 549 | - | expression tag |
| His 550 | - | expression tag |
| His 551 | - | expression tag |
| His 552 | - | expression tag |
| Ser 553 | - | expression tag |
| Ser 554 | - | expression tag |
| Gly 555 | - | expression tag |
| Leu 556 | - | expression tag |
| Val 557 | - | expression tag |
| Pro 558 | - | expression tag |
| Arg 559 | - | expression tag |
| Gly 560 | - | expression tag |
| Ser 561 | - | expression tag |
| His 562 | - | expression tag |
| Met 563 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 109574.8 | |
| All* | Total formula weight | 109574.8 |
