8BDI
VCB in complex with compound 32
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | J | Elongin-B | polymer | 104 | 11852.4 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
2 | K, E, H, B | Elongin-C | polymer | 97 | 10974.6 | 4 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
3 | L, F, I, C | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18806.3 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | Homo sapiens (human) | Protein G7,pVHL |
4 | D, G, A | Elongin-B | polymer | 104 | 11748.4 | 3 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
5 | L, F, I, C | (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 587.7 | 4 | Chemie (QF7) | |||
6 | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
K, E, H, B: 17 - 112 (UniProt: Q15369)
L, F, I, C: 54 - 213 (UniProt: P40337)
PDB | External Database | Details |
---|---|---|
Met 16 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Gly 52 | - | expression tag |
Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 166221.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2350.8 | |
All* | Total formula weight | 168572.0 |