8BDI

VCB in complex with compound 32

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (J)	Elongin-B	polymer	104	11852.4	1	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E, H, K (K, E, H, B)	Elongin-C	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, I, L (L, F, I, C)	von Hippel-Lindau disease tumor suppressor	polymer	162	18806.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
4	D, G, J (D, G, A)	Elongin-B	polymer	104	11748.4	3	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
5	M, N, O, P (L, F, I, C)	(2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		587.7	4	Chemie (QF7)
6	AA, BA, Q, R, S... (B, C, J, K, L...)	water	water		18.0	636	Chemie (HOH)

Sequence modifications

K, E, H, B: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

L, F, I, C: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	166221.2
Non-Polymers*	Number of molecules	4
	Total formula weight	2350.8
All*	Total formula weight	168572.0

*Water molecules are not included.