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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8B9D

Human replisome bound by Pol Alpha

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)		DNA replication licensing factor MCM2polymer904102034.11UniProt (P49736)
Pfam (PF12619)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)		Homo sapiens (human)Minichromosome maintenance protein 2 homolog,Nuclear protein BM28
2B
(3)		DNA replication licensing factor MCM3polymer80891110.91UniProt (P25205)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)		Homo sapiens (human)DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102
3C
(4)		DNA replication licensing factor MCM4polymer86396684.91UniProt (P33991)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)		Homo sapiens (human)CDC21 homolog,P1-CDC21
4D
(5)		DNA replication licensing factor MCM5polymer73482406.61UniProt (P33992)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)
Pfam (PF21933)		Homo sapiens (human)CDC46 homolog,P1-CDC46
5E
(6)		DNA replication licensing factor MCM6polymer82193010.31UniProt (Q14566)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)
Pfam (PF18263)		Homo sapiens (human)p105MCM
6F
(7)		DNA replication licensing factor MCM7polymer71981411.91UniProt (P33993)
Pfam (PF14551)
Pfam (PF17207)
Pfam (PF00493)
Pfam (PF17855)		Homo sapiens (human)CDC47 homolog,P1.1-MCM3
7G
(A)		DNA polymerase alpha subunit Bpolymer59866015.51UniProt (Q14181)
Pfam (PF08418)
Pfam (PF22062)
Pfam (PF04042)		Homo sapiens (human)DNA polymerase alpha 70 kDa subunit
8H
(C)		Cell division control protein 45 homologpolymer56966016.91UniProt (O75419)
Pfam (PF02724)		Homo sapiens (human)PORC-PI-1
9I
(D)		DNA replication complex GINS protein PSF1polymer19623022.51UniProt (Q14691)
Pfam (PF05916)		Homo sapiens (human)GINS complex subunit 1
10J
(E)		DNA replication complex GINS protein PSF2polymer18521453.71UniProt (Q9Y248)
Pfam (PF05916)		Homo sapiens (human)GINS complex subunit 2
11K
(F)		DNA replication complex GINS protein PSF3polymer21624562.61UniProt (Q9BRX5)
Pfam (PF22466)
Pfam (PF05916)		Homo sapiens (human)GINS complex subunit 3
12L
(G)		DNA replication complex GINS protein SLD5polymer26129983.01UniProt (Q9BRT9)
Pfam (PF05916)
Pfam (PF16922)		Homo sapiens (human)GINS complex subunit 4
13M
(K)		Protein timeless homologpolymer1209138903.01UniProt (Q9UNS1)
Pfam (PF04821)
Pfam (PF05029)		Homo sapiens (human)hTIM
14N
(L)		TIMELESS-interacting proteinpolymer30134600.21UniProt (Q9BVW5)
Pfam (PF07962)		Homo sapiens (human)
15O
(M)		Leading strand DNApolymer8426092.61Homo sapiens
16P
(N)		DNA Moleculepolymer8626402.91Homo sapiens
17Q
(P)		DNA primase large subunitpolymer50958890.91UniProt (P49643)
Pfam (PF04104)		Homo sapiens (human)DNA primase 58 kDa subunit,p58
18R
(Q)		Claspinpolymer1371155184.71UniProt (Q9HAW4)Homo sapiens (human)hClaspin
19S
(O)		DNA primase small subunitpolymer46254242.61UniProt (P49642)
Pfam (PF01896)		Homo sapiens (human)DNA primase 49 kDa subunit,p49
20T, V, W
(H, J, I)		WD repeat and HMG-box DNA-binding protein 1polymer1160129967.03UniProt (O75717)
Pfam (PF00400)
Pfam (PF12894)
Pfam (PF12341)
Pfam (PF20946)		Homo sapiens (human)Acidic nucleoplasmic DNA-binding protein 1,And-1
21U
(B)		DNA polymerase alpha catalytic subunitpolymer1504170392.71UniProt (P09884)
Pfam (PF12254)
Pfam (PF03104)
Pfam (PF00136)
Pfam (PF08996)		Homo sapiens (human)DNA polymerase alpha catalytic subunit p180
22DA, X, Z
(5, 2, 3)		PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.23Chemie (ANP)
23AA, EA, Y
(3, 5, 2)		MAGNESIUM IONnon-polymer24.33Chemie (MG)
24BA, CA, FA, GA
(4, 5, 6, 7)		ZINC IONnon-polymer65.44Chemie (ZN)
Sequence modifications
C: 1 - 134 (UniProt: O75419)
C: 135 - 566 (UniProt: O75419)
PDBExternal DatabaseDetails
Asp 135-linker
Tyr 135-linker
Lys 135-linker
Asp 135-linker
Asp 135-linker
Asp 135-linker
G: 1 - 223 (UniProt: Q9BRT9)
PDBExternal DatabaseDetails
Trp -37-expression tag
Ser -36-expression tag
His -35-expression tag
Pro -34-expression tag
Gln -33-expression tag
Phe -32-expression tag
Glu -31-expression tag
Lys -30-expression tag
Gly -29-expression tag
Gly -28-expression tag
Gly -27-expression tag
Ser -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
Gly -21-expression tag
Gly -20-expression tag
Ser -19-expression tag
Ala -18-expression tag
Trp -17-expression tag
Ser -16-expression tag
His -15-expression tag
Pro -14-expression tag
Gln -13-expression tag
Phe -12-expression tag
Glu -11-expression tag
Lys -10-expression tag
Ser -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
K: 1 - 1208 (UniProt: Q9UNS1)
PDBExternal DatabaseDetails
Gly 0-expression tag
Q: 1 - 1339 (UniProt: Q9HAW4)
PDBExternal DatabaseDetails
Leu 1340-expression tag
Glu 1341-expression tag
Val 1342-expression tag
Leu 1343-expression tag
Phe 1344-expression tag
Gln 1345-expression tag
Gly 1346-expression tag
Pro 1347-expression tag
Asp 1348-expression tag
Tyr 1349-expression tag
Lys 1350-expression tag
Asp 1351-expression tag
Asp 1352-expression tag
Asp 1353-expression tag
Asp 1354-expression tag
Lys 1355-expression tag
Asp 1356-expression tag
Tyr 1357-expression tag
Lys 1358-expression tag
Asp 1359-expression tag
Asp 1360-expression tag
Asp 1361-expression tag
Asp 1362-expression tag
Lys 1363-expression tag
Asp 1364-expression tag
Tyr 1365-expression tag
Lys 1366-expression tag
Asp 1367-expression tag
Asp 1368-expression tag
Asp 1369-expression tag
Asp 1370-expression tag
Lys 1371-expression tag
O: 1 - 420 (UniProt: P49642)
PDBExternal DatabaseDetails
Met -41-initiating methionine
Ala -40-expression tag
Ser -39-expression tag
Ala -38-expression tag
Trp -37-expression tag
Ser -36-expression tag
His -35-expression tag
Pro -34-expression tag
Gln -33-expression tag
Phe -32-expression tag
Glu -31-expression tag
Lys -30-expression tag
Gly -29-expression tag
Gly -28-expression tag
Gly -27-expression tag
Ser -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
Gly -21-expression tag
Gly -20-expression tag
Ser -19-expression tag
Ala -18-expression tag
Trp -17-expression tag
Ser -16-expression tag
His -15-expression tag
Pro -14-expression tag
Gln -13-expression tag
Phe -12-expression tag
Glu -11-expression tag
Lys -10-expression tag
Ser -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
H, J, I: 1 - 1129 (UniProt: O75717)
PDBExternal DatabaseDetails
Asp -30-expression tag
Tyr -29-expression tag
Lys -28-expression tag
Asp -27-expression tag
Asp -26-expression tag
Asp -25-expression tag
Asp -24-expression tag
Lys -23-expression tag
Asp -22-expression tag
Tyr -21-expression tag
Lys -20-expression tag
Asp -19-expression tag
Asp -18-expression tag
Asp -17-expression tag
Asp -16-expression tag
Lys -15-expression tag
Asp -14-expression tag
Tyr -13-expression tag
Lys -12-expression tag
Asp -11-expression tag
Asp -10-expression tag
Asp -9-expression tag
Asp -8-expression tag
Lys -7-expression tag
Glu -6-expression tag
Asn -5-expression tag
Leu -4-expression tag
Tyr -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Gly 0-expression tag
B: 1 - 1462 (UniProt: P09884)
PDBExternal DatabaseDetails
Met -41-initiating methionine
Ala -40-expression tag
Ser -39-expression tag
Ala -38-expression tag
Trp -37-expression tag
Ser -36-expression tag
His -35-expression tag
Pro -34-expression tag
Gln -33-expression tag
Phe -32-expression tag
Glu -31-expression tag
Lys -30-expression tag
Gly -29-expression tag
Gly -28-expression tag
Gly -27-expression tag
Ser -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
Gly -21-expression tag
Gly -20-expression tag
Ser -19-expression tag
Ala -18-expression tag
Trp -17-expression tag
Ser -16-expression tag
His -15-expression tag
Pro -14-expression tag
Gln -13-expression tag
Phe -12-expression tag
Glu -11-expression tag
Lys -10-expression tag
Ser -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains23
Total formula weight1832323.4
Non-Polymers*Number of molecules10
Total formula weight1853.1
All*Total formula weight1834176.5
*Water molecules are not included.

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PDB entries from 2025-11-05

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