8B6M
Tankyrase 2 in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 171 | 19482.1 | 2 | UniProt (Q9H2K2) Pfam (PF00644) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 2 | B, D (B, D) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 48 | 5364.0 | 2 | UniProt (Q9H2K2) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 3 | E, K (A, C) | ~{N}-(2-methoxyphenyl)-4-[[2-(4-oxidanylidene-3~{H}-quinazolin-2-yl)ethyl-(thiophen-2-ylmethyl)carbamoyl]amino]benzamide | non-polymer | 553.6 | 2 | Chemie (OY6) | |||
| 4 | F, G, L, M (A, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | H, J (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A, C: 946 - 1114 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 49692.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1714.4 | |
| All* | Total formula weight | 51406.6 |
