8B6H
Cryo-EM structure of cytochrome c oxidase dimer (complex IV) from respiratory supercomplex of Tetrahymena thermophila
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, AB (DA, Da) | Cytochrome c oxidase subunit 1 | polymer | 688 | 80579.0 | 2 | UniProt (Q950Y4) Pfam (PF00115) | Tetrahymena thermophila SB210 | |
| 2 | B, BB (DB, Db) | Cytochrome c oxidase subunit 2 | polymer | 604 | 72388.9 | 2 | UniProt (Q950Y9) Pfam (PF00116) | Tetrahymena thermophila SB210 | |
| 3 | C, CB (DC, Dc) | Ymf68 | polymer | 594 | 72782.5 | 2 | UniProt (Q950Y6) | Tetrahymena thermophila SB210 | |
| 4 | D, DB (DD, Dd) | Cytochrome C oxidase subunit Vb protein | polymer | 637 | 75431.3 | 2 | UniProt (Q23FF5) Pfam (PF01215) | Tetrahymena thermophila SB210 | |
| 5 | E, EB (DE, De) | Transmembrane protein, putative | polymer | 130 | 15618.3 | 2 | UniProt (W7XCY5) | Tetrahymena thermophila SB210 | |
| 6 | F, FB (DF, Df) | Structural protein | polymer | 230 | 27946.4 | 2 | UniProt (Q24I72) | Tetrahymena thermophila SB210 | |
| 7 | G, GB (DG, Dg) | Transmembrane protein, putative | polymer | 103 | 12786.3 | 2 | UniProt (Q23DS4) | Tetrahymena thermophila SB210 | |
| 8 | H, HB (DH, Dh) | Transmembrane protein, putative | polymer | 133 | 16427.7 | 2 | UniProt (I7MGF9) | Tetrahymena thermophila SB210 | |
| 9 | I, IB (DI, Di) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 236 | 28666.7 | 2 | UniProt (W7X287) | Tetrahymena thermophila SB210 | |
| 10 | J, JB (DJ, Dj) | Transmembrane protein, putative | polymer | 220 | 26601.2 | 2 | UniProt (W7WZP1) | Tetrahymena thermophila SB210 | |
| 11 | K, KB (DK, Dk) | CTF/NF-I domain-containing protein | polymer | 990 | 116812.8 | 2 | UniProt (Q22CI1) | Tetrahymena thermophila SB210 | |
| 12 | L, LB (DM, Dm) | Transmembrane protein, putative | polymer | 490 | 57814.5 | 2 | UniProt (Q22PJ5) | Tetrahymena thermophila SB210 | |
| 13 | M, MB (DN, Dn) | Ymf67 | polymer | 453 | 54538.5 | 2 | UniProt (Q950Y7) | Tetrahymena thermophila SB210 | |
| 14 | N, NB (DO, Do) | Protein phosphatase 2C, putative | polymer | 473 | 53011.3 | 2 | UniProt (Q22FX8) | Tetrahymena thermophila SB210 | |
| 15 | O, OB (DP, Dp) | SURF1-like protein | polymer | 402 | 47088.0 | 2 | UniProt (I7M1Q4) Pfam (PF02104) | Tetrahymena thermophila SB210 | |
| 16 | P, PB (DQ, Dq) | TraB family protein | polymer | 385 | 45064.9 | 2 | UniProt (Q23DP7) | Tetrahymena thermophila SB210 | |
| 17 | Q, QB (DR, Dr) | Transmembrane protein, putative | polymer | 348 | 41307.4 | 2 | UniProt (Q23DG8) | Tetrahymena thermophila SB210 | |
| 18 | R, RB (DS, Ds) | Oxoglutarate/malate translocator protein, putative | polymer | 346 | 40434.3 | 2 | UniProt (A4VDV3) Pfam (PF00153) | Tetrahymena thermophila SB210 | |
| 19 | S, SB (DT, Dt) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, mitochondrial | polymer | 318 | 37553.0 | 2 | UniProt (Q23DZ5) | Tetrahymena thermophila SB210 | |
| 20 | T, TB (DU, Du) | Carrier protein | polymer | 330 | 37095.1 | 2 | UniProt (Q22ZA6) Pfam (PF00153) | Tetrahymena thermophila SB210 | |
| 21 | U, UB (DV, Dv) | 2-oxoglutarate/malate carrier protein | polymer | 318 | 36132.3 | 2 | UniProt (Q23M99) Pfam (PF00153) | Tetrahymena thermophila SB210 | |
| 22 | V, VB (DW, Dw) | SURF1-like protein | polymer | 318 | 35794.4 | 2 | UniProt (I7LTZ4) Pfam (PF02104) | Tetrahymena thermophila SB210 | |
| 23 | W, WB (DX, Dx) | COXTT9 | polymer | 252 | 29865.7 | 2 | UniProt (I7LY65) | Tetrahymena thermophila SB210 | |
| 24 | X, XB (DY, Dy) | COXTT10 | polymer | 234 | 28101.5 | 2 | UniProt (I7MD70) | Tetrahymena thermophila SB210 | |
| 25 | Y, YB (DZ, Dz) | 39S ribosomal protein L9, mitochondrial | polymer | 231 | 27034.7 | 2 | UniProt (W7X4J9) | Tetrahymena thermophila SB210 | |
| 26 | Z, ZB (EA, Ea) | COXTT12,Transmembrane protein,Transmembrane protein | polymer | 215 | 25953.8 | 2 | UniProt (I7M3P9) | Tetrahymena thermophila SB210 | |
| 27 | AA, AC (EB, Eb) | Transmembrane protein, putative | polymer | 210 | 24701.1 | 2 | UniProt (I7LZX8) | Tetrahymena thermophila SB210 | |
| 28 | BA, BC (EC, Ec) | COXTT27 | polymer | 212 | 23368.4 | 2 | Tetrahymena thermophila SB210 | ||
| 29 | CA, CC (ED, Ed) | Ymf75 | polymer | 190 | 23325.8 | 2 | UniProt (Q951A7) | Tetrahymena thermophila SB210 | |
| 30 | DA, DC (EE, Ee) | Mobilization protein | polymer | 193 | 23257.7 | 2 | UniProt (Q23F08) | Tetrahymena thermophila SB210 | |
| 31 | EA, EC (EF, Ef) | Iron-binding zinc finger CDGSH type protein | polymer | 188 | 21476.9 | 2 | UniProt (I7M8P0) | Tetrahymena thermophila SB210 | |
| 32 | FA, FC (EG, Eg) | COXTT28 | polymer | 100 | 11121.6 | 2 | Tetrahymena thermophila SB210 | ||
| 33 | GA, GC (EH, Eh) | Transmembrane protein, putative | polymer | 173 | 20388.3 | 2 | UniProt (Q23D87) | Tetrahymena thermophila SB210 | |
| 34 | HA, HC (EI, Ei) | Transmembrane protein | polymer | 173 | 20025.1 | 2 | UniProt (I7MKT6) | Tetrahymena thermophila SB210 | |
| 35 | IA, IC (EV, Ev) | Decapping nuclease | polymer | 88 | 10242.7 | 2 | UniProt (I7LVX0) | Tetrahymena thermophila SB210 | |
| 36 | JA, JC (EK, Ek) | Complex III subunit VII | polymer | 170 | 19882.8 | 2 | UniProt (Q230X6) | Tetrahymena thermophila SB210 | |
| 37 | KA, KC (EL, El) | Transmembrane protein, putative | polymer | 158 | 18801.6 | 2 | UniProt (Q23VY4) | Tetrahymena thermophila SB210 | |
| 38 | LA, LC (EM, Em) | Transmembrane protein, putative | polymer | 154 | 18600.4 | 2 | UniProt (Q22DP8) | Tetrahymena thermophila SB210 | |
| 39 | MA, MC (EN, En) | COXTT22 | polymer | 149 | 17701.1 | 2 | UniProt (I7MFV5) | Tetrahymena thermophila SB210 | |
| 40 | NA, NC (EO, Eo) | Transmembrane protein, putative | polymer | 124 | 15588.6 | 2 | UniProt (Q23TE5) | Tetrahymena thermophila SB210 | |
| 41 | OA, OC (EP, Ep) | Phage protein | polymer | 127 | 14740.9 | 2 | UniProt (Q24C97) | Tetrahymena thermophila SB210 | |
| 42 | PA, PC (EQ, Eq) | Transmembrane protein, putative | polymer | 122 | 14344.5 | 2 | UniProt (Q22W32) | Tetrahymena thermophila SB210 | |
| 43 | QA, QC (ER, Er) | Lysozyme | polymer | 105 | 12273.9 | 2 | UniProt (I7M9E7) | Tetrahymena thermophila SB210 | |
| 44 | RA, RC (ES, Es) | Ymf70 | polymer | 89 | 10891.9 | 2 | UniProt (Q950Y0) | Tetrahymena thermophila SB210 | |
| 45 | SA, SC (ET, Et) | Zf-Tim10_DDP domain-containing protein | polymer | 93 | 10435.7 | 2 | UniProt (Q231A8) | Tetrahymena thermophila SB210 | |
| 46 | TA, TC (EU, Eu) | ABC transporter | polymer | 90 | 10418.7 | 2 | UniProt (I7LTF1) | Tetrahymena thermophila SB210 | |
| 47 | UA, UC (EJ, Ej) | YflT domain-containing protein | polymer | 175 | 19979.3 | 2 | UniProt (I7M8Y9) | Tetrahymena thermophila SB210 | |
| 48 | VA, VC (EW, Ew) | Cullin domain-containing protein | polymer | 81 | 8965.9 | 2 | UniProt (Q22N23) | Tetrahymena thermophila SB210 | |
| 49 | WA, WC (EX, Ex) | Zf-Tim10_DDP domain-containing protein | polymer | 72 | 8354.6 | 2 | UniProt (W7XDM6) | Tetrahymena thermophila SB210 | |
| 50 | XA, XC (EY, Ey) | Annexin | polymer | 72 | 8155.4 | 2 | UniProt (Q233U0) | Tetrahymena thermophila SB210 | |
| 51 | YA, YC (EZ, Ez) | Transposase | polymer | 68 | 8081.1 | 2 | UniProt (Q22A35) | Tetrahymena thermophila SB210 | |
| 52 | ZA, ZC (FA, Fa) | Tim10/DDP family zinc finger protein | polymer | 72 | 8009.0 | 2 | UniProt (W7X3D6) Pfam (PF02953) | Tetrahymena thermophila SB210 | |
| 53 | AD, BD (Dl, DL) | COXBP,Chromosome condensation regulator RCC1 repeat protein,Chromosome condensation regulator RCC1 repeat protein | polymer | 536 | 58697.8 | 2 | UniProt (Q22RF2) Pfam (PF00415) | Tetrahymena thermophila SB210 | |
| 54 | CD, DD, TH, UH (DA, Da) | HEME-A | non-polymer | 852.8 | 4 | Chemie (HEA) | |||
| 55 | ED, VH (DA, Da) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) | |||
| 56 | FD, WH (DA, Da) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 57 | AE, AF, AH, AJ, BE... (DD, DQ, EL, Dj, Da...) | CARDIOLIPIN | non-polymer | 1464.0 | 118 | Chemie (CDL) | |||
| 58 | AG, BL, CF, DL, EG... (DX, Dx, DQ, Dy, Db...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 54 | Chemie (PC1) | |||
| 59 | AI, AK, AL, AM, BG... (Da, Dr, Dx, Em, DX...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 34 | Chemie (3PE) | |||
| 60 | KL, MD, MM, NJ, PJ... (Ed, DA, Dl, Dn, DN...) | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE | non-polymer | 648.9 | 8 | Chemie (LPP) | |||
| 61 | CI, ND (Da, DA) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 62 | DI, OD (Db, DB) | DINUCLEAR COPPER ION | non-polymer | 127.1 | 2 | Chemie (CUA) | |||
| 63 | MI, YD (Dd, DD) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 64 | CE (DD) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 65 | DM, EH, EK, JH, JL... (En, EL, Ds, EN, Ed...) | Ubiquinone-8 | non-polymer | 727.1 | 8 | Chemie (UQ8) | |||
| 66 | IL, PG (Ed, ED) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 67 | OL, PL, SG, TG (Ef, EF) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 68 | KM, RH (Er, ER) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
DA, Da: 1 - 688 (UniProt: Q950Y4)
EA, Ea: 8 - 21 (PDB: 8B6H)
EA, Ea: 22 - 222 (UniProt: I7M3P9)
Dl, DL: -73 - 82 (PDB: 8B6H)
Dl, DL: 83 - 411 (UniProt: Q22RF2)
Dl, DL: 412 - 462 (PDB: 8B6H)
| PDB | External Database | Details |
|---|---|---|
| Ala 288 | Gly 288 | variant |
EA, Ea: 22 - 222 (UniProt: I7M3P9)
Dl, DL: -73 - 82 (PDB: 8B6H)
Dl, DL: 83 - 411 (UniProt: Q22RF2)
Dl, DL: 412 - 462 (PDB: 8B6H)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 106 |
| Total formula weight | 3209322.2 | |
| Non-Polymers* | Number of molecules | 245 |
| Total formula weight | 258909.0 | |
| All* | Total formula weight | 3468231.3 |
