8B6H

Cryo-EM structure of cytochrome c oxidase dimer (complex IV) from respiratory supercomplex of Tetrahymena thermophila

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Da	0004129	molecular_function	cytochrome-c oxidase activity
Da	0005739	cellular_component	mitochondrion
Da	0005743	cellular_component	mitochondrial inner membrane
Da	0005751	cellular_component	mitochondrial respiratory chain complex IV
Da	0006119	biological_process	oxidative phosphorylation
Da	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Da	0009060	biological_process	aerobic respiration
Da	0015990	biological_process	electron transport coupled proton transport
Da	0016020	cellular_component	membrane
Da	0016491	molecular_function	oxidoreductase activity
Da	0020037	molecular_function	heme binding
Da	0046872	molecular_function	metal ion binding
Da	0070469	cellular_component	respirasome
DA	0004129	molecular_function	cytochrome-c oxidase activity
DA	0005739	cellular_component	mitochondrion
DA	0005743	cellular_component	mitochondrial inner membrane
DA	0005751	cellular_component	mitochondrial respiratory chain complex IV
DA	0006119	biological_process	oxidative phosphorylation
DA	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
DA	0009060	biological_process	aerobic respiration
DA	0015990	biological_process	electron transport coupled proton transport
DA	0016020	cellular_component	membrane
DA	0016491	molecular_function	oxidoreductase activity
DA	0020037	molecular_function	heme binding
DA	0046872	molecular_function	metal ion binding
DA	0070469	cellular_component	respirasome
Db	0004129	molecular_function	cytochrome-c oxidase activity
Db	0005507	molecular_function	copper ion binding
Db	0005739	cellular_component	mitochondrion
Db	0016020	cellular_component	membrane
Db	0016491	molecular_function	oxidoreductase activity
Db	0042773	biological_process	ATP synthesis coupled electron transport
Db	1902600	biological_process	proton transmembrane transport
DB	0004129	molecular_function	cytochrome-c oxidase activity
DB	0005507	molecular_function	copper ion binding
DB	0005739	cellular_component	mitochondrion
DB	0016020	cellular_component	membrane
DB	0016491	molecular_function	oxidoreductase activity
DB	0042773	biological_process	ATP synthesis coupled electron transport
DB	1902600	biological_process	proton transmembrane transport
Dc	0005739	cellular_component	mitochondrion
Dc	0016020	cellular_component	membrane
DC	0005739	cellular_component	mitochondrion
DC	0016020	cellular_component	membrane
Dd	0005740	cellular_component	mitochondrial envelope
Dd	0005751	cellular_component	mitochondrial respiratory chain complex IV
Dd	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Dd	0046872	molecular_function	metal ion binding
DD	0005740	cellular_component	mitochondrial envelope
DD	0005751	cellular_component	mitochondrial respiratory chain complex IV
DD	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
DD	0046872	molecular_function	metal ion binding
De	0016020	cellular_component	membrane
DE	0016020	cellular_component	membrane
Dg	0016020	cellular_component	membrane
DG	0016020	cellular_component	membrane
Dh	0016020	cellular_component	membrane
DH	0016020	cellular_component	membrane
Dj	0016020	cellular_component	membrane
DJ	0016020	cellular_component	membrane
Dk	0003700	molecular_function	DNA-binding transcription factor activity
Dk	0005634	cellular_component	nucleus
Dk	0006355	biological_process	regulation of DNA-templated transcription
Dk	0010468	biological_process	regulation of gene expression
DK	0003700	molecular_function	DNA-binding transcription factor activity
DK	0005634	cellular_component	nucleus
DK	0006355	biological_process	regulation of DNA-templated transcription
DK	0010468	biological_process	regulation of gene expression
Dm	0016020	cellular_component	membrane
DM	0016020	cellular_component	membrane
Dn	0005739	cellular_component	mitochondrion
Dn	0016020	cellular_component	membrane
DN	0005739	cellular_component	mitochondrion
DN	0016020	cellular_component	membrane
Dp	0005739	cellular_component	mitochondrion
Dp	0005743	cellular_component	mitochondrial inner membrane
Dp	0005783	cellular_component	endoplasmic reticulum
Dp	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
Dp	0007030	biological_process	Golgi organization
Dp	0016020	cellular_component	membrane
Dp	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
DP	0005739	cellular_component	mitochondrion
DP	0005743	cellular_component	mitochondrial inner membrane
DP	0005783	cellular_component	endoplasmic reticulum
DP	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
DP	0007030	biological_process	Golgi organization
DP	0016020	cellular_component	membrane
DP	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
Dr	0016020	cellular_component	membrane
DR	0016020	cellular_component	membrane
Ds	0016020	cellular_component	membrane
Ds	0022857	molecular_function	transmembrane transporter activity
Ds	0055085	biological_process	transmembrane transport
DS	0016020	cellular_component	membrane
DS	0022857	molecular_function	transmembrane transporter activity
DS	0055085	biological_process	transmembrane transport
Du	0016020	cellular_component	membrane
DU	0016020	cellular_component	membrane
Dv	0005310	molecular_function	dicarboxylic acid transmembrane transporter activity
Dv	0008272	biological_process	sulfate transport
Dv	0015116	molecular_function	sulfate transmembrane transporter activity
Dv	0015117	molecular_function	thiosulfate transmembrane transporter activity
Dv	0015131	molecular_function	oxaloacetate transmembrane transporter activity
Dv	0015140	molecular_function	malate transmembrane transporter activity
Dv	0015141	molecular_function	succinate transmembrane transporter activity
Dv	0015297	molecular_function	antiporter activity
Dv	0015709	biological_process	thiosulfate transport
Dv	0015729	biological_process	oxaloacetate transport
Dv	0016020	cellular_component	membrane
Dv	0035435	biological_process	phosphate ion transmembrane transport
Dv	0071422	biological_process	succinate transmembrane transport
Dv	0071423	biological_process	malate transmembrane transport
Dv	1902356	biological_process	oxaloacetate(2-) transmembrane transport
Dv	1902358	biological_process	sulfate transmembrane transport
DV	0005310	molecular_function	dicarboxylic acid transmembrane transporter activity
DV	0008272	biological_process	sulfate transport
DV	0015116	molecular_function	sulfate transmembrane transporter activity
DV	0015117	molecular_function	thiosulfate transmembrane transporter activity
DV	0015131	molecular_function	oxaloacetate transmembrane transporter activity
DV	0015140	molecular_function	malate transmembrane transporter activity
DV	0015141	molecular_function	succinate transmembrane transporter activity
DV	0015297	molecular_function	antiporter activity
DV	0015709	biological_process	thiosulfate transport
DV	0015729	biological_process	oxaloacetate transport
DV	0016020	cellular_component	membrane
DV	0035435	biological_process	phosphate ion transmembrane transport
DV	0071422	biological_process	succinate transmembrane transport
DV	0071423	biological_process	malate transmembrane transport
DV	1902356	biological_process	oxaloacetate(2-) transmembrane transport
DV	1902358	biological_process	sulfate transmembrane transport
Dw	0005739	cellular_component	mitochondrion
Dw	0005743	cellular_component	mitochondrial inner membrane
Dw	0005783	cellular_component	endoplasmic reticulum
Dw	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
Dw	0007030	biological_process	Golgi organization
Dw	0016020	cellular_component	membrane
Dw	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
DW	0005739	cellular_component	mitochondrion
DW	0005743	cellular_component	mitochondrial inner membrane
DW	0005783	cellular_component	endoplasmic reticulum
DW	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
DW	0007030	biological_process	Golgi organization
DW	0016020	cellular_component	membrane
DW	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
Eb	0016020	cellular_component	membrane
EB	0016020	cellular_component	membrane
Ed	0005739	cellular_component	mitochondrion
Ed	0016020	cellular_component	membrane
ED	0005739	cellular_component	mitochondrion
ED	0016020	cellular_component	membrane
Ef	0005737	cellular_component	cytoplasm
Ef	0005739	cellular_component	mitochondrion
Ef	0016020	cellular_component	membrane
Ef	0043231	cellular_component	intracellular membrane-bounded organelle
Ef	0046872	molecular_function	metal ion binding
Ef	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Ef	0106034	biological_process	protein maturation by [2Fe-2S] cluster transfer
EF	0005737	cellular_component	cytoplasm
EF	0005739	cellular_component	mitochondrion
EF	0016020	cellular_component	membrane
EF	0043231	cellular_component	intracellular membrane-bounded organelle
EF	0046872	molecular_function	metal ion binding
EF	0051537	molecular_function	2 iron, 2 sulfur cluster binding
EF	0106034	biological_process	protein maturation by [2Fe-2S] cluster transfer
Eh	0016020	cellular_component	membrane
EH	0016020	cellular_component	membrane
El	0016020	cellular_component	membrane
EL	0016020	cellular_component	membrane
Em	0016020	cellular_component	membrane
EM	0016020	cellular_component	membrane
Eq	0016020	cellular_component	membrane
EQ	0016020	cellular_component	membrane
Es	0005739	cellular_component	mitochondrion
Es	0016020	cellular_component	membrane
ES	0005739	cellular_component	mitochondrion
ES	0016020	cellular_component	membrane
Fa	0005739	cellular_component	mitochondrion
Fa	0005743	cellular_component	mitochondrial inner membrane
Fa	0015031	biological_process	protein transport
FA	0005739	cellular_component	mitochondrion
FA	0005743	cellular_component	mitochondrial inner membrane
FA	0015031	biological_process	protein transport

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCgiSqsGPwC

Chain	Residue	Details
EF	CYS99-CYS110

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site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyvliiptfgfinmivphnntrrvaskhhmiwaiyvmaymgylvwg..HH

Chain	Residue	Details
DA	TRP387-HIS441

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site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. LLFfllregslqrCmgCGqvFKL

Chain	Residue	Details
DD	LEU175-LEU197

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