8B4F
Crystal structure of human cathepsin L forming a thiohemiacetal with N-Boc-2-aminoacetaldehyde
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) In PDB | Homo sapiens (human) | |
| 2 | A, B, C, D | ~{tert}-butyl ~{N}-(2-hydroxyethyl)carbamate | non-polymer | 161.2 | 4 | Chemie (OYU) | |||
| 3 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 4 | D, A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 6 | D, A, B, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 9 | Chemie (PEG) | |||
| 7 | A, C | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 8 | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 2550.0 | |
| All* | Total formula weight | 99196.7 |
