8AXS

Sialidases and Fucosidases of Akkermansia muciniphila are key for rapid growth on colonic mucin and nutrient sharing amongst mucin-associated human gut microbiota

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Exo-alpha-sialidase	polymer	578	64362.6	1	UniProt (A0A7G6DVF6)	Akkermansia muciniphila
2	B (B)	Exo-alpha-sialidase	polymer	576	64278.4	1	UniProt (A0A7G6DVF6)	Akkermansia muciniphila
3	C, D, M (A, B)	N-acetyl-beta-neuraminic acid	non-polymer		309.3	3	Chemie (SLB)
4	E (A)	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
5	F, G, H, O, P... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
6	I, J, R, S (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
7	K, T (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	L (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
9	N (B)	2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID	non-polymer		291.3	1	Chemie (DAN)
10	U, V (A, B)	water	water		18.0	1416	Chemie (HOH)

Sequence modifications

A: 23 - 595 (UniProt: A0A7G6DVF6)

PDB	External Database	Details
Met 22	-	initiating methionine
Val 477	Ala 477	conflict
Lys 516	Arg 516	conflict
Ala 598	-	expression tag
Ala 599	-	expression tag
Ala 600	-	expression tag
Ala 601	-	expression tag

B: 23 - 595 (UniProt: A0A7G6DVF6)

PDB	External Database	Details
Met 22	-	initiating methionine
Val 477	Ala 477	conflict
Lys 516	Arg 516	conflict
Ala 596	-	expression tag
Glu 597	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128641.0
Non-Polymers*	Number of molecules	18
	Total formula weight	1978.6
All*	Total formula weight	130619.6

*Water molecules are not included.