8AXD

Human serotonin 5-HT3A receptor (apo, resting conformation)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	5-hydroxytryptamine receptor 3A	polymer	555	62821.8	5	UniProt (P46098) Pfam (PF02931) Pfam (PF02932) In PDB	Homo sapiens (human)	5-HT3-A,5-HT3A,5-hydroxytryptamine receptor 3,5-HT-3,5-HT3R,Serotonin receptor 3A,Serotonin-gated ion channel receptor
2	F, G, H, I, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
3	A, B, C, D, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)

Sequence modifications

A, B, C, D, E: 27 - 478 (UniProt: P46098)

PDB	External Database	Details
Met -76	-	initiating methionine
Leu -75	-	expression tag
Leu -74	-	expression tag
Trp -73	-	expression tag
Val -72	-	expression tag
Gln -71	-	expression tag
Gln -70	-	expression tag
Ala -69	-	expression tag
Leu -68	-	expression tag
Leu -67	-	expression tag
Ala -66	-	expression tag
Leu -65	-	expression tag
Leu -64	-	expression tag
Leu -63	-	expression tag
Pro -62	-	expression tag
Thr -61	-	expression tag
Leu -60	-	expression tag
Leu -59	-	expression tag
Ala -58	-	expression tag
Gln -57	-	expression tag
Gly -56	-	expression tag
Glu -55	-	expression tag
Ala -54	-	expression tag
Arg -53	-	expression tag
Arg -52	-	expression tag
Ser -51	-	expression tag
Trp -50	-	expression tag
Ser -49	-	expression tag
His -48	-	expression tag
Pro -47	-	expression tag
Gln -46	-	expression tag
Phe -45	-	expression tag
Glu -44	-	expression tag
Lys -43	-	expression tag
Gly -42	-	expression tag
Gly -41	-	expression tag
Gly -40	-	expression tag
Ser -39	-	expression tag
Gly -38	-	expression tag
Gly -37	-	expression tag
Gly -36	-	expression tag
Ser -35	-	expression tag
Gly -34	-	expression tag
Gly -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Trp -30	-	expression tag
Ser -29	-	expression tag
His -28	-	expression tag
Pro -27	-	expression tag
Gln -26	-	expression tag
Phe -25	-	expression tag
Glu -24	-	expression tag
Lys -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Gly -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Gly -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Trp -10	-	expression tag
Ser -9	-	expression tag
His -8	-	expression tag
Pro -7	-	expression tag
Gln -6	-	expression tag
Phe -5	-	expression tag
Glu -4	-	expression tag
Lys -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Gly 2	-	expression tag
Gly 3	-	expression tag
Gly 4	-	expression tag
Ser 5	-	expression tag
Gly 6	-	expression tag
Gly 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
Trp 10	-	expression tag
Ser 11	-	expression tag
His 12	-	expression tag
Pro 13	-	expression tag
Gln 14	-	expression tag
Phe 15	-	expression tag
Glu 16	-	expression tag
Lys 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Gly 24	-	expression tag
Ser 25	-	expression tag
Gly 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	314109.1
Branched	Number of molecules	5
	Total formula weight	2122.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	317337.1

*Water molecules are not included.