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8AXD

Human serotonin 5-HT3A receptor (apo, resting conformation)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007210biological_processserotonin receptor signaling pathway
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0022850molecular_functionserotonin-gated monoatomic cation channel activity
A0032154cellular_componentcleavage furrow
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051378molecular_functionserotonin binding
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A0098662biological_processinorganic cation transmembrane transport
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1902495cellular_componenttransmembrane transporter complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904602cellular_componentserotonin-activated cation-selective channel complex
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007210biological_processserotonin receptor signaling pathway
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0022850molecular_functionserotonin-gated monoatomic cation channel activity
B0032154cellular_componentcleavage furrow
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051378molecular_functionserotonin binding
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
B0098662biological_processinorganic cation transmembrane transport
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1902495cellular_componenttransmembrane transporter complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904602cellular_componentserotonin-activated cation-selective channel complex
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007210biological_processserotonin receptor signaling pathway
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0022850molecular_functionserotonin-gated monoatomic cation channel activity
C0032154cellular_componentcleavage furrow
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051378molecular_functionserotonin binding
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
C0098662biological_processinorganic cation transmembrane transport
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1902495cellular_componenttransmembrane transporter complex
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1904602cellular_componentserotonin-activated cation-selective channel complex
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007210biological_processserotonin receptor signaling pathway
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0022850molecular_functionserotonin-gated monoatomic cation channel activity
D0032154cellular_componentcleavage furrow
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051378molecular_functionserotonin binding
D0060078biological_processregulation of postsynaptic membrane potential
D0060079biological_processexcitatory postsynaptic potential
D0098662biological_processinorganic cation transmembrane transport
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1902495cellular_componenttransmembrane transporter complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1904602cellular_componentserotonin-activated cation-selective channel complex
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0007210biological_processserotonin receptor signaling pathway
E0015276molecular_functionligand-gated monoatomic ion channel activity
E0016020cellular_componentmembrane
E0022850molecular_functionserotonin-gated monoatomic cation channel activity
E0032154cellular_componentcleavage furrow
E0034220biological_processmonoatomic ion transmembrane transport
E0042802molecular_functionidentical protein binding
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051378molecular_functionserotonin binding
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E0098662biological_processinorganic cation transmembrane transport
E0099505biological_processregulation of presynaptic membrane potential
E0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E1902495cellular_componenttransmembrane transporter complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904602cellular_componentserotonin-activated cation-selective channel complex
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC
ChainResidueDetails
ACYS157-CYS171

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
APRO242-PRO268
BPRO242-PRO268
CPRO242-PRO268
DPRO242-PRO268
EPRO242-PRO268

site_idSWS_FT_FI2
Number of Residues685
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P23979
ChainResidueDetails
AASN269-ARG273
EGLU322-HIS455
AGLU322-HIS455
BASN269-ARG273
BGLU322-HIS455
CASN269-ARG273
CGLU322-HIS455
DASN269-ARG273
DGLU322-HIS455
EASN269-ARG273

site_idSWS_FT_FI3
Number of Residues90
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AVAL274-SER292
BVAL274-SER292
CVAL274-SER292
DVAL274-SER292
EVAL274-SER292

site_idSWS_FT_FI4
Number of Residues55
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P23979
ChainResidueDetails
AASP293-THR302
EGLN476-ALA478
AGLN476-ALA478
BASP293-THR302
BGLN476-ALA478
CASP293-THR302
CGLN476-ALA478
DASP293-THR302
DGLN476-ALA478
EASP293-THR302

site_idSWS_FT_FI5
Number of Residues90
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
APRO303-ALA321
BPRO303-ALA321
CPRO303-ALA321
DPRO303-ALA321
EPRO303-ALA321

site_idSWS_FT_FI6
Number of Residues95
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AILE456-TRP475
BILE456-TRP475
CILE456-TRP475
DILE456-TRP475
EILE456-TRP475

site_idSWS_FT_FI7
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN28
CASN104
CASN170
CASN186
DASN28
DASN104
DASN170
DASN186
EASN28
EASN104
EASN170
AASN104
EASN186
AASN170
AASN186
BASN28
BASN104
BASN170
BASN186
CASN28

223166

PDB entries from 2024-07-31

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