8AUK
Cryo-EM structure of human BIRC6 in complex with HTRA2.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Baculoviral IAP repeat-containing protein 6 | polymer | 4867 | 532009.0 | 2 | UniProt (Q9NR09) Pfam (PF00653) Pfam (PF12356) Pfam (PF00179) | Homo sapiens (human) | BIR repeat-containing ubiquitin-conjugating enzyme,BRUCE,RING-type E3 ubiquitin transferase BIRC6,Ubiquitin-conjugating BIR domain enzyme apollon,APOLLON |
| 2 | C, D, E (D, E, C) | Serine protease HTRA2, mitochondrial | polymer | 325 | 35001.8 | 3 | UniProt (O43464) Pfam (PF13365) Pfam (PF17820) | Homo sapiens (human) | High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI |
| 3 | F, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 4857 (UniProt: Q9NR09)
D, E, C: 134 - 458 (UniProt: O43464)
| PDB | External Database | Details |
|---|---|---|
| Val 1332 | Leu 1332 | conflict |
| Ser 4858 | - | expression tag |
| Ala 4859 | - | expression tag |
| Trp 4860 | - | expression tag |
| Ser 4861 | - | expression tag |
| His 4862 | - | expression tag |
| Pro 4863 | - | expression tag |
| Gln 4864 | - | expression tag |
| Phe 4865 | - | expression tag |
| Glu 4866 | - | expression tag |
| Lys 4867 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 306 | Ser 306 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 1169023.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 1169154.3 |
