8ASN
Crystal structure of the apo human TTL in complex with tubulin-stathmin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
2 | B, D | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | |
3 | E | Stathmin-4 | polymer | 143 | 16883.2 | 1 | UniProt (P63043) Pfam (PF00836) In PDB | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
4 | F, G, H, I | Tubulin--tyrosine ligase | polymer | 383 | 43984.9 | 4 | UniProt (Q8NG68) Pfam (PF03133) In PDB | Homo sapiens (human) | TTL |
5 | A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
6 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
7 | B, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
8 | F, G, H, I | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 4 | Chemie (ACP) | |||
9 | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F, G, H, I: 3 - 379 (UniProt: Q8NG68)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
Ala 4 | - | expression tag |
Trp 20 | Phe 64 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 2 | - | expression tag |
Glu 380 | - | expression tag |
Asn 381 | - | expression tag |
Leu 382 | - | expression tag |
Tyr 383 | - | expression tag |
Phe 384 | - | expression tag |
Gln 385 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 393231.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4050.8 | |
All* | Total formula weight | 397282.1 |