8ARI

Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	C-terminal-binding protein 1	polymer	457	49525.3	24	UniProt (Q13363) Pfam (PF00389) Pfam (PF02826)	Homo sapiens (human)	CtBP1
2	AA, BA, CA, DA, EA... (a, b, c, d, e...)	Retinoic acid-induced protein 2	polymer	129	14252.8	10	UniProt (Q9Y5P3)	Homo sapiens (human)
3	AB, BB, CB, DB, EB... (S, T, U, V, W...)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	24	Chemie (NAD)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X: 1 - 440 (UniProt: Q13363)

PDB	External Database	Details
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ala -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

a, b, c, d, e, f, g, h, i, j: 303 - 362 (UniProt: Q9Y5P3)

PDB	External Database	Details
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
Pro 229	-	expression tag
Met 230	-	expression tag
Lys 231	-	expression tag
Gln 232	-	expression tag
Tyr 233	-	expression tag
Lys 234	-	expression tag
Leu 235	-	expression tag
Ile 236	-	expression tag
Leu 237	-	expression tag
Asn 238	-	expression tag
Gly 239	-	expression tag
Lys 240	-	expression tag
Thr 241	-	expression tag
Leu 242	-	expression tag
Lys 243	-	expression tag
Gly 244	-	expression tag
Glu 245	-	expression tag
Thr 246	-	expression tag
Thr 247	-	expression tag
Thr 248	-	expression tag
Glu 249	-	expression tag
Ala 250	-	expression tag
Val 251	-	expression tag
Asp 252	-	expression tag
Ala 253	-	expression tag
Ala 254	-	expression tag
Thr 255	-	expression tag
Ala 256	-	expression tag
Glu 257	-	expression tag
Lys 258	-	expression tag
Val 259	-	expression tag
Phe 260	-	expression tag
Lys 261	-	expression tag
Gln 262	-	expression tag
Tyr 263	-	expression tag
Ala 264	-	expression tag
Asn 265	-	expression tag
Asp 266	-	expression tag
Asn 267	-	expression tag
Gly 268	-	expression tag
Val 269	-	expression tag
Asp 270	-	expression tag
Gly 271	-	expression tag
Glu 272	-	expression tag
Trp 273	-	expression tag
Thr 274	-	expression tag
Tyr 275	-	expression tag
Asp 276	-	expression tag
Asp 277	-	expression tag
Ala 278	-	expression tag
Thr 279	-	expression tag
Lys 280	-	expression tag
Thr 281	-	expression tag
Phe 282	-	expression tag
Thr 283	-	expression tag
Val 284	-	expression tag
Thr 285	-	expression tag
Glu 286	-	expression tag
Gly 287	-	expression tag
Ser 288	-	expression tag
Gly 289	-	expression tag
Ser 290	-	expression tag
Gly 291	-	expression tag
Ser 292	-	expression tag
Glu 293	-	expression tag
Asn 294	-	expression tag
Leu 295	-	expression tag
Tyr 296	-	expression tag
Phe 297	-	expression tag
Gln 298	-	expression tag
Gly 299	-	expression tag
Ala 300	-	expression tag
Met 301	-	expression tag
Asp 302	-	expression tag
-	Glu 331	deletion
-	Val 332	deletion
-	Ser 333	deletion
-	Pro 334	deletion
-	Pro 335	deletion
-	Ile 336	deletion
-	Phe 337	deletion
-	Gln 338	deletion
-	Glu 339	deletion
-	Asp 340	deletion
-	Ala 341	deletion

Contents of the asymmetric unit

Polymers	Number of chains	34
	Total formula weight	1331135.9
Non-Polymers*	Number of molecules	24
	Total formula weight	15922.2
All*	Total formula weight	1347058.1

*Water molecules are not included.