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8ARI

Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament

Functional Information from GO Data
ChainGOidnamespacecontents
a0005618cellular_componentcell wall
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001221molecular_functiontranscription coregulator binding
A0001222molecular_functiontranscription corepressor binding
A0003682molecular_functionchromatin binding
A0003713molecular_functiontranscription coactivator activity
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0008285biological_processnegative regulation of cell population proliferation
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0017053cellular_componenttranscription repressor complex
A0019079biological_processviral genome replication
A0019904molecular_functionprotein domain specific binding
A0030154biological_processcell differentiation
A0042802molecular_functionidentical protein binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0048488biological_processsynaptic vesicle endocytosis
A0050872biological_processwhite fat cell differentiation
A0051287molecular_functionNAD binding
A0051726biological_processregulation of cell cycle
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0097091biological_processsynaptic vesicle clustering
A0098831cellular_componentpresynaptic active zone cytoplasmic component
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0140297molecular_functionDNA-binding transcription factor binding
b0005618cellular_componentcell wall
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001221molecular_functiontranscription coregulator binding
B0001222molecular_functiontranscription corepressor binding
B0003682molecular_functionchromatin binding
B0003713molecular_functiontranscription coactivator activity
B0003714molecular_functiontranscription corepressor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0008285biological_processnegative regulation of cell population proliferation
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0017053cellular_componenttranscription repressor complex
B0019079biological_processviral genome replication
B0019904molecular_functionprotein domain specific binding
B0030154biological_processcell differentiation
B0042802molecular_functionidentical protein binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0048488biological_processsynaptic vesicle endocytosis
B0050872biological_processwhite fat cell differentiation
B0051287molecular_functionNAD binding
B0051726biological_processregulation of cell cycle
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0097091biological_processsynaptic vesicle clustering
B0098831cellular_componentpresynaptic active zone cytoplasmic component
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0140297molecular_functionDNA-binding transcription factor binding
c0005618cellular_componentcell wall
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001221molecular_functiontranscription coregulator binding
C0001222molecular_functiontranscription corepressor binding
C0003682molecular_functionchromatin binding
C0003713molecular_functiontranscription coactivator activity
C0003714molecular_functiontranscription corepressor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0006357biological_processregulation of transcription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0008285biological_processnegative regulation of cell population proliferation
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0017053cellular_componenttranscription repressor complex
C0019079biological_processviral genome replication
C0019904molecular_functionprotein domain specific binding
C0030154biological_processcell differentiation
C0042802molecular_functionidentical protein binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0048488biological_processsynaptic vesicle endocytosis
C0050872biological_processwhite fat cell differentiation
C0051287molecular_functionNAD binding
C0051726biological_processregulation of cell cycle
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0097091biological_processsynaptic vesicle clustering
C0098831cellular_componentpresynaptic active zone cytoplasmic component
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C0140297molecular_functionDNA-binding transcription factor binding
d0005618cellular_componentcell wall
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001221molecular_functiontranscription coregulator binding
D0001222molecular_functiontranscription corepressor binding
D0003682molecular_functionchromatin binding
D0003713molecular_functiontranscription coactivator activity
D0003714molecular_functiontranscription corepressor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0006357biological_processregulation of transcription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0008285biological_processnegative regulation of cell population proliferation
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0017053cellular_componenttranscription repressor complex
D0019079biological_processviral genome replication
D0019904molecular_functionprotein domain specific binding
D0030154biological_processcell differentiation
D0042802molecular_functionidentical protein binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0048488biological_processsynaptic vesicle endocytosis
D0050872biological_processwhite fat cell differentiation
D0051287molecular_functionNAD binding
D0051726biological_processregulation of cell cycle
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0097091biological_processsynaptic vesicle clustering
D0098831cellular_componentpresynaptic active zone cytoplasmic component
D0098978cellular_componentglutamatergic synapse
D0098982cellular_componentGABA-ergic synapse
D0140297molecular_functionDNA-binding transcription factor binding
e0005618cellular_componentcell wall
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001221molecular_functiontranscription coregulator binding
E0001222molecular_functiontranscription corepressor binding
E0003682molecular_functionchromatin binding
E0003713molecular_functiontranscription coactivator activity
E0003714molecular_functiontranscription corepressor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0006357biological_processregulation of transcription by RNA polymerase II
E0006468biological_processprotein phosphorylation
E0008285biological_processnegative regulation of cell population proliferation
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0017053cellular_componenttranscription repressor complex
E0019079biological_processviral genome replication
E0019904molecular_functionprotein domain specific binding
E0030154biological_processcell differentiation
E0042802molecular_functionidentical protein binding
E0045892biological_processnegative regulation of DNA-templated transcription
E0045893biological_processpositive regulation of DNA-templated transcription
E0048488biological_processsynaptic vesicle endocytosis
E0050872biological_processwhite fat cell differentiation
E0051287molecular_functionNAD binding
E0051726biological_processregulation of cell cycle
E0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
E0097091biological_processsynaptic vesicle clustering
E0098831cellular_componentpresynaptic active zone cytoplasmic component
E0098978cellular_componentglutamatergic synapse
E0098982cellular_componentGABA-ergic synapse
E0140297molecular_functionDNA-binding transcription factor binding
f0005618cellular_componentcell wall
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0001221molecular_functiontranscription coregulator binding
F0001222molecular_functiontranscription corepressor binding
F0003682molecular_functionchromatin binding
F0003713molecular_functiontranscription coactivator activity
F0003714molecular_functiontranscription corepressor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0006357biological_processregulation of transcription by RNA polymerase II
F0006468biological_processprotein phosphorylation
F0008285biological_processnegative regulation of cell population proliferation
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0017053cellular_componenttranscription repressor complex
F0019079biological_processviral genome replication
F0019904molecular_functionprotein domain specific binding
F0030154biological_processcell differentiation
F0042802molecular_functionidentical protein binding
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0048488biological_processsynaptic vesicle endocytosis
F0050872biological_processwhite fat cell differentiation
F0051287molecular_functionNAD binding
F0051726biological_processregulation of cell cycle
F0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
F0097091biological_processsynaptic vesicle clustering
F0098831cellular_componentpresynaptic active zone cytoplasmic component
F0098978cellular_componentglutamatergic synapse
F0098982cellular_componentGABA-ergic synapse
F0140297molecular_functionDNA-binding transcription factor binding
g0005618cellular_componentcell wall
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0001221molecular_functiontranscription coregulator binding
G0001222molecular_functiontranscription corepressor binding
G0003682molecular_functionchromatin binding
G0003713molecular_functiontranscription coactivator activity
G0003714molecular_functiontranscription corepressor activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0006357biological_processregulation of transcription by RNA polymerase II
G0006468biological_processprotein phosphorylation
G0008285biological_processnegative regulation of cell population proliferation
G0016491molecular_functionoxidoreductase activity
G0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G0017053cellular_componenttranscription repressor complex
G0019079biological_processviral genome replication
G0019904molecular_functionprotein domain specific binding
G0030154biological_processcell differentiation
G0042802molecular_functionidentical protein binding
G0045892biological_processnegative regulation of DNA-templated transcription
G0045893biological_processpositive regulation of DNA-templated transcription
G0048488biological_processsynaptic vesicle endocytosis
G0050872biological_processwhite fat cell differentiation
G0051287molecular_functionNAD binding
G0051726biological_processregulation of cell cycle
G0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
G0097091biological_processsynaptic vesicle clustering
G0098831cellular_componentpresynaptic active zone cytoplasmic component
G0098978cellular_componentglutamatergic synapse
G0098982cellular_componentGABA-ergic synapse
G0140297molecular_functionDNA-binding transcription factor binding
h0005618cellular_componentcell wall
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0001221molecular_functiontranscription coregulator binding
H0001222molecular_functiontranscription corepressor binding
H0003682molecular_functionchromatin binding
H0003713molecular_functiontranscription coactivator activity
H0003714molecular_functiontranscription corepressor activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0006357biological_processregulation of transcription by RNA polymerase II
H0006468biological_processprotein phosphorylation
H0008285biological_processnegative regulation of cell population proliferation
H0016491molecular_functionoxidoreductase activity
H0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H0017053cellular_componenttranscription repressor complex
H0019079biological_processviral genome replication
H0019904molecular_functionprotein domain specific binding
H0030154biological_processcell differentiation
H0042802molecular_functionidentical protein binding
H0045892biological_processnegative regulation of DNA-templated transcription
H0045893biological_processpositive regulation of DNA-templated transcription
H0048488biological_processsynaptic vesicle endocytosis
H0050872biological_processwhite fat cell differentiation
H0051287molecular_functionNAD binding
H0051726biological_processregulation of cell cycle
H0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
H0097091biological_processsynaptic vesicle clustering
H0098831cellular_componentpresynaptic active zone cytoplasmic component
H0098978cellular_componentglutamatergic synapse
H0098982cellular_componentGABA-ergic synapse
H0140297molecular_functionDNA-binding transcription factor binding
i0005618cellular_componentcell wall
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0001221molecular_functiontranscription coregulator binding
I0001222molecular_functiontranscription corepressor binding
I0003682molecular_functionchromatin binding
I0003713molecular_functiontranscription coactivator activity
I0003714molecular_functiontranscription corepressor activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0006357biological_processregulation of transcription by RNA polymerase II
I0006468biological_processprotein phosphorylation
I0008285biological_processnegative regulation of cell population proliferation
I0016491molecular_functionoxidoreductase activity
I0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I0017053cellular_componenttranscription repressor complex
I0019079biological_processviral genome replication
I0019904molecular_functionprotein domain specific binding
I0030154biological_processcell differentiation
I0042802molecular_functionidentical protein binding
I0045892biological_processnegative regulation of DNA-templated transcription
I0045893biological_processpositive regulation of DNA-templated transcription
I0048488biological_processsynaptic vesicle endocytosis
I0050872biological_processwhite fat cell differentiation
I0051287molecular_functionNAD binding
I0051726biological_processregulation of cell cycle
I0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
I0097091biological_processsynaptic vesicle clustering
I0098831cellular_componentpresynaptic active zone cytoplasmic component
I0098978cellular_componentglutamatergic synapse
I0098982cellular_componentGABA-ergic synapse
I0140297molecular_functionDNA-binding transcription factor binding
j0005618cellular_componentcell wall
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0001221molecular_functiontranscription coregulator binding
J0001222molecular_functiontranscription corepressor binding
J0003682molecular_functionchromatin binding
J0003713molecular_functiontranscription coactivator activity
J0003714molecular_functiontranscription corepressor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0006357biological_processregulation of transcription by RNA polymerase II
J0006468biological_processprotein phosphorylation
J0008285biological_processnegative regulation of cell population proliferation
J0016491molecular_functionoxidoreductase activity
J0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J0017053cellular_componenttranscription repressor complex
J0019079biological_processviral genome replication
J0019904molecular_functionprotein domain specific binding
J0030154biological_processcell differentiation
J0042802molecular_functionidentical protein binding
J0045892biological_processnegative regulation of DNA-templated transcription
J0045893biological_processpositive regulation of DNA-templated transcription
J0048488biological_processsynaptic vesicle endocytosis
J0050872biological_processwhite fat cell differentiation
J0051287molecular_functionNAD binding
J0051726biological_processregulation of cell cycle
J0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
J0097091biological_processsynaptic vesicle clustering
J0098831cellular_componentpresynaptic active zone cytoplasmic component
J0098978cellular_componentglutamatergic synapse
J0098982cellular_componentGABA-ergic synapse
J0140297molecular_functionDNA-binding transcription factor binding
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0001221molecular_functiontranscription coregulator binding
K0001222molecular_functiontranscription corepressor binding
K0003682molecular_functionchromatin binding
K0003713molecular_functiontranscription coactivator activity
K0003714molecular_functiontranscription corepressor activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0006357biological_processregulation of transcription by RNA polymerase II
K0006468biological_processprotein phosphorylation
K0008285biological_processnegative regulation of cell population proliferation
K0016491molecular_functionoxidoreductase activity
K0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K0017053cellular_componenttranscription repressor complex
K0019079biological_processviral genome replication
K0019904molecular_functionprotein domain specific binding
K0030154biological_processcell differentiation
K0042802molecular_functionidentical protein binding
K0045892biological_processnegative regulation of DNA-templated transcription
K0045893biological_processpositive regulation of DNA-templated transcription
K0048488biological_processsynaptic vesicle endocytosis
K0050872biological_processwhite fat cell differentiation
K0051287molecular_functionNAD binding
K0051726biological_processregulation of cell cycle
K0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
K0097091biological_processsynaptic vesicle clustering
K0098831cellular_componentpresynaptic active zone cytoplasmic component
K0098978cellular_componentglutamatergic synapse
K0098982cellular_componentGABA-ergic synapse
K0140297molecular_functionDNA-binding transcription factor binding
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0001221molecular_functiontranscription coregulator binding
L0001222molecular_functiontranscription corepressor binding
L0003682molecular_functionchromatin binding
L0003713molecular_functiontranscription coactivator activity
L0003714molecular_functiontranscription corepressor activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0006357biological_processregulation of transcription by RNA polymerase II
L0006468biological_processprotein phosphorylation
L0008285biological_processnegative regulation of cell population proliferation
L0016491molecular_functionoxidoreductase activity
L0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L0017053cellular_componenttranscription repressor complex
L0019079biological_processviral genome replication
L0019904molecular_functionprotein domain specific binding
L0030154biological_processcell differentiation
L0042802molecular_functionidentical protein binding
L0045892biological_processnegative regulation of DNA-templated transcription
L0045893biological_processpositive regulation of DNA-templated transcription
L0048488biological_processsynaptic vesicle endocytosis
L0050872biological_processwhite fat cell differentiation
L0051287molecular_functionNAD binding
L0051726biological_processregulation of cell cycle
L0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
L0097091biological_processsynaptic vesicle clustering
L0098831cellular_componentpresynaptic active zone cytoplasmic component
L0098978cellular_componentglutamatergic synapse
L0098982cellular_componentGABA-ergic synapse
L0140297molecular_functionDNA-binding transcription factor binding
M0000122biological_processnegative regulation of transcription by RNA polymerase II
M0001221molecular_functiontranscription coregulator binding
M0001222molecular_functiontranscription corepressor binding
M0003682molecular_functionchromatin binding
M0003713molecular_functiontranscription coactivator activity
M0003714molecular_functiontranscription corepressor activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0006357biological_processregulation of transcription by RNA polymerase II
M0006468biological_processprotein phosphorylation
M0008285biological_processnegative regulation of cell population proliferation
M0016491molecular_functionoxidoreductase activity
M0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
M0017053cellular_componenttranscription repressor complex
M0019079biological_processviral genome replication
M0019904molecular_functionprotein domain specific binding
M0030154biological_processcell differentiation
M0042802molecular_functionidentical protein binding
M0045892biological_processnegative regulation of DNA-templated transcription
M0045893biological_processpositive regulation of DNA-templated transcription
M0048488biological_processsynaptic vesicle endocytosis
M0050872biological_processwhite fat cell differentiation
M0051287molecular_functionNAD binding
M0051726biological_processregulation of cell cycle
M0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
M0097091biological_processsynaptic vesicle clustering
M0098831cellular_componentpresynaptic active zone cytoplasmic component
M0098978cellular_componentglutamatergic synapse
M0098982cellular_componentGABA-ergic synapse
M0140297molecular_functionDNA-binding transcription factor binding
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0001221molecular_functiontranscription coregulator binding
N0001222molecular_functiontranscription corepressor binding
N0003682molecular_functionchromatin binding
N0003713molecular_functiontranscription coactivator activity
N0003714molecular_functiontranscription corepressor activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0006357biological_processregulation of transcription by RNA polymerase II
N0006468biological_processprotein phosphorylation
N0008285biological_processnegative regulation of cell population proliferation
N0016491molecular_functionoxidoreductase activity
N0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
N0017053cellular_componenttranscription repressor complex
N0019079biological_processviral genome replication
N0019904molecular_functionprotein domain specific binding
N0030154biological_processcell differentiation
N0042802molecular_functionidentical protein binding
N0045892biological_processnegative regulation of DNA-templated transcription
N0045893biological_processpositive regulation of DNA-templated transcription
N0048488biological_processsynaptic vesicle endocytosis
N0050872biological_processwhite fat cell differentiation
N0051287molecular_functionNAD binding
N0051726biological_processregulation of cell cycle
N0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
N0097091biological_processsynaptic vesicle clustering
N0098831cellular_componentpresynaptic active zone cytoplasmic component
N0098978cellular_componentglutamatergic synapse
N0098982cellular_componentGABA-ergic synapse
N0140297molecular_functionDNA-binding transcription factor binding
O0000122biological_processnegative regulation of transcription by RNA polymerase II
O0001221molecular_functiontranscription coregulator binding
O0001222molecular_functiontranscription corepressor binding
O0003682molecular_functionchromatin binding
O0003713molecular_functiontranscription coactivator activity
O0003714molecular_functiontranscription corepressor activity
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005737cellular_componentcytoplasm
O0006357biological_processregulation of transcription by RNA polymerase II
O0006468biological_processprotein phosphorylation
O0008285biological_processnegative regulation of cell population proliferation
O0016491molecular_functionoxidoreductase activity
O0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
O0017053cellular_componenttranscription repressor complex
O0019079biological_processviral genome replication
O0019904molecular_functionprotein domain specific binding
O0030154biological_processcell differentiation
O0042802molecular_functionidentical protein binding
O0045892biological_processnegative regulation of DNA-templated transcription
O0045893biological_processpositive regulation of DNA-templated transcription
O0048488biological_processsynaptic vesicle endocytosis
O0050872biological_processwhite fat cell differentiation
O0051287molecular_functionNAD binding
O0051726biological_processregulation of cell cycle
O0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
O0097091biological_processsynaptic vesicle clustering
O0098831cellular_componentpresynaptic active zone cytoplasmic component
O0098978cellular_componentglutamatergic synapse
O0098982cellular_componentGABA-ergic synapse
O0140297molecular_functionDNA-binding transcription factor binding
P0000122biological_processnegative regulation of transcription by RNA polymerase II
P0001221molecular_functiontranscription coregulator binding
P0001222molecular_functiontranscription corepressor binding
P0003682molecular_functionchromatin binding
P0003713molecular_functiontranscription coactivator activity
P0003714molecular_functiontranscription corepressor activity
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0006357biological_processregulation of transcription by RNA polymerase II
P0006468biological_processprotein phosphorylation
P0008285biological_processnegative regulation of cell population proliferation
P0016491molecular_functionoxidoreductase activity
P0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
P0017053cellular_componenttranscription repressor complex
P0019079biological_processviral genome replication
P0019904molecular_functionprotein domain specific binding
P0030154biological_processcell differentiation
P0042802molecular_functionidentical protein binding
P0045892biological_processnegative regulation of DNA-templated transcription
P0045893biological_processpositive regulation of DNA-templated transcription
P0048488biological_processsynaptic vesicle endocytosis
P0050872biological_processwhite fat cell differentiation
P0051287molecular_functionNAD binding
P0051726biological_processregulation of cell cycle
P0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
P0097091biological_processsynaptic vesicle clustering
P0098831cellular_componentpresynaptic active zone cytoplasmic component
P0098978cellular_componentglutamatergic synapse
P0098982cellular_componentGABA-ergic synapse
P0140297molecular_functionDNA-binding transcription factor binding
Q0000122biological_processnegative regulation of transcription by RNA polymerase II
Q0001221molecular_functiontranscription coregulator binding
Q0001222molecular_functiontranscription corepressor binding
Q0003682molecular_functionchromatin binding
Q0003713molecular_functiontranscription coactivator activity
Q0003714molecular_functiontranscription corepressor activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005737cellular_componentcytoplasm
Q0006357biological_processregulation of transcription by RNA polymerase II
Q0006468biological_processprotein phosphorylation
Q0008285biological_processnegative regulation of cell population proliferation
Q0016491molecular_functionoxidoreductase activity
Q0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Q0017053cellular_componenttranscription repressor complex
Q0019079biological_processviral genome replication
Q0019904molecular_functionprotein domain specific binding
Q0030154biological_processcell differentiation
Q0042802molecular_functionidentical protein binding
Q0045892biological_processnegative regulation of DNA-templated transcription
Q0045893biological_processpositive regulation of DNA-templated transcription
Q0048488biological_processsynaptic vesicle endocytosis
Q0050872biological_processwhite fat cell differentiation
Q0051287molecular_functionNAD binding
Q0051726biological_processregulation of cell cycle
Q0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
Q0097091biological_processsynaptic vesicle clustering
Q0098831cellular_componentpresynaptic active zone cytoplasmic component
Q0098978cellular_componentglutamatergic synapse
Q0098982cellular_componentGABA-ergic synapse
Q0140297molecular_functionDNA-binding transcription factor binding
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0001221molecular_functiontranscription coregulator binding
R0001222molecular_functiontranscription corepressor binding
R0003682molecular_functionchromatin binding
R0003713molecular_functiontranscription coactivator activity
R0003714molecular_functiontranscription corepressor activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0006357biological_processregulation of transcription by RNA polymerase II
R0006468biological_processprotein phosphorylation
R0008285biological_processnegative regulation of cell population proliferation
R0016491molecular_functionoxidoreductase activity
R0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
R0017053cellular_componenttranscription repressor complex
R0019079biological_processviral genome replication
R0019904molecular_functionprotein domain specific binding
R0030154biological_processcell differentiation
R0042802molecular_functionidentical protein binding
R0045892biological_processnegative regulation of DNA-templated transcription
R0045893biological_processpositive regulation of DNA-templated transcription
R0048488biological_processsynaptic vesicle endocytosis
R0050872biological_processwhite fat cell differentiation
R0051287molecular_functionNAD binding
R0051726biological_processregulation of cell cycle
R0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
R0097091biological_processsynaptic vesicle clustering
R0098831cellular_componentpresynaptic active zone cytoplasmic component
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0140297molecular_functionDNA-binding transcription factor binding
S0000122biological_processnegative regulation of transcription by RNA polymerase II
S0001221molecular_functiontranscription coregulator binding
S0001222molecular_functiontranscription corepressor binding
S0003682molecular_functionchromatin binding
S0003713molecular_functiontranscription coactivator activity
S0003714molecular_functiontranscription corepressor activity
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005737cellular_componentcytoplasm
S0006357biological_processregulation of transcription by RNA polymerase II
S0006468biological_processprotein phosphorylation
S0008285biological_processnegative regulation of cell population proliferation
S0016491molecular_functionoxidoreductase activity
S0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
S0017053cellular_componenttranscription repressor complex
S0019079biological_processviral genome replication
S0019904molecular_functionprotein domain specific binding
S0030154biological_processcell differentiation
S0042802molecular_functionidentical protein binding
S0045892biological_processnegative regulation of DNA-templated transcription
S0045893biological_processpositive regulation of DNA-templated transcription
S0048488biological_processsynaptic vesicle endocytosis
S0050872biological_processwhite fat cell differentiation
S0051287molecular_functionNAD binding
S0051726biological_processregulation of cell cycle
S0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
S0097091biological_processsynaptic vesicle clustering
S0098831cellular_componentpresynaptic active zone cytoplasmic component
S0098978cellular_componentglutamatergic synapse
S0098982cellular_componentGABA-ergic synapse
S0140297molecular_functionDNA-binding transcription factor binding
T0000122biological_processnegative regulation of transcription by RNA polymerase II
T0001221molecular_functiontranscription coregulator binding
T0001222molecular_functiontranscription corepressor binding
T0003682molecular_functionchromatin binding
T0003713molecular_functiontranscription coactivator activity
T0003714molecular_functiontranscription corepressor activity
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005737cellular_componentcytoplasm
T0006357biological_processregulation of transcription by RNA polymerase II
T0006468biological_processprotein phosphorylation
T0008285biological_processnegative regulation of cell population proliferation
T0016491molecular_functionoxidoreductase activity
T0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
T0017053cellular_componenttranscription repressor complex
T0019079biological_processviral genome replication
T0019904molecular_functionprotein domain specific binding
T0030154biological_processcell differentiation
T0042802molecular_functionidentical protein binding
T0045892biological_processnegative regulation of DNA-templated transcription
T0045893biological_processpositive regulation of DNA-templated transcription
T0048488biological_processsynaptic vesicle endocytosis
T0050872biological_processwhite fat cell differentiation
T0051287molecular_functionNAD binding
T0051726biological_processregulation of cell cycle
T0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
T0097091biological_processsynaptic vesicle clustering
T0098831cellular_componentpresynaptic active zone cytoplasmic component
T0098978cellular_componentglutamatergic synapse
T0098982cellular_componentGABA-ergic synapse
T0140297molecular_functionDNA-binding transcription factor binding
U0000122biological_processnegative regulation of transcription by RNA polymerase II
U0001221molecular_functiontranscription coregulator binding
U0001222molecular_functiontranscription corepressor binding
U0003682molecular_functionchromatin binding
U0003713molecular_functiontranscription coactivator activity
U0003714molecular_functiontranscription corepressor activity
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005737cellular_componentcytoplasm
U0006357biological_processregulation of transcription by RNA polymerase II
U0006468biological_processprotein phosphorylation
U0008285biological_processnegative regulation of cell population proliferation
U0016491molecular_functionoxidoreductase activity
U0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
U0017053cellular_componenttranscription repressor complex
U0019079biological_processviral genome replication
U0019904molecular_functionprotein domain specific binding
U0030154biological_processcell differentiation
U0042802molecular_functionidentical protein binding
U0045892biological_processnegative regulation of DNA-templated transcription
U0045893biological_processpositive regulation of DNA-templated transcription
U0048488biological_processsynaptic vesicle endocytosis
U0050872biological_processwhite fat cell differentiation
U0051287molecular_functionNAD binding
U0051726biological_processregulation of cell cycle
U0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
U0097091biological_processsynaptic vesicle clustering
U0098831cellular_componentpresynaptic active zone cytoplasmic component
U0098978cellular_componentglutamatergic synapse
U0098982cellular_componentGABA-ergic synapse
U0140297molecular_functionDNA-binding transcription factor binding
V0000122biological_processnegative regulation of transcription by RNA polymerase II
V0001221molecular_functiontranscription coregulator binding
V0001222molecular_functiontranscription corepressor binding
V0003682molecular_functionchromatin binding
V0003713molecular_functiontranscription coactivator activity
V0003714molecular_functiontranscription corepressor activity
V0005515molecular_functionprotein binding
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005737cellular_componentcytoplasm
V0006357biological_processregulation of transcription by RNA polymerase II
V0006468biological_processprotein phosphorylation
V0008285biological_processnegative regulation of cell population proliferation
V0016491molecular_functionoxidoreductase activity
V0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
V0017053cellular_componenttranscription repressor complex
V0019079biological_processviral genome replication
V0019904molecular_functionprotein domain specific binding
V0030154biological_processcell differentiation
V0042802molecular_functionidentical protein binding
V0045892biological_processnegative regulation of DNA-templated transcription
V0045893biological_processpositive regulation of DNA-templated transcription
V0048488biological_processsynaptic vesicle endocytosis
V0050872biological_processwhite fat cell differentiation
V0051287molecular_functionNAD binding
V0051726biological_processregulation of cell cycle
V0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
V0097091biological_processsynaptic vesicle clustering
V0098831cellular_componentpresynaptic active zone cytoplasmic component
V0098978cellular_componentglutamatergic synapse
V0098982cellular_componentGABA-ergic synapse
V0140297molecular_functionDNA-binding transcription factor binding
W0000122biological_processnegative regulation of transcription by RNA polymerase II
W0001221molecular_functiontranscription coregulator binding
W0001222molecular_functiontranscription corepressor binding
W0003682molecular_functionchromatin binding
W0003713molecular_functiontranscription coactivator activity
W0003714molecular_functiontranscription corepressor activity
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0006357biological_processregulation of transcription by RNA polymerase II
W0006468biological_processprotein phosphorylation
W0008285biological_processnegative regulation of cell population proliferation
W0016491molecular_functionoxidoreductase activity
W0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
W0017053cellular_componenttranscription repressor complex
W0019079biological_processviral genome replication
W0019904molecular_functionprotein domain specific binding
W0030154biological_processcell differentiation
W0042802molecular_functionidentical protein binding
W0045892biological_processnegative regulation of DNA-templated transcription
W0045893biological_processpositive regulation of DNA-templated transcription
W0048488biological_processsynaptic vesicle endocytosis
W0050872biological_processwhite fat cell differentiation
W0051287molecular_functionNAD binding
W0051726biological_processregulation of cell cycle
W0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
W0097091biological_processsynaptic vesicle clustering
W0098831cellular_componentpresynaptic active zone cytoplasmic component
W0098978cellular_componentglutamatergic synapse
W0098982cellular_componentGABA-ergic synapse
W0140297molecular_functionDNA-binding transcription factor binding
X0000122biological_processnegative regulation of transcription by RNA polymerase II
X0001221molecular_functiontranscription coregulator binding
X0001222molecular_functiontranscription corepressor binding
X0003682molecular_functionchromatin binding
X0003713molecular_functiontranscription coactivator activity
X0003714molecular_functiontranscription corepressor activity
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0006357biological_processregulation of transcription by RNA polymerase II
X0006468biological_processprotein phosphorylation
X0008285biological_processnegative regulation of cell population proliferation
X0016491molecular_functionoxidoreductase activity
X0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
X0017053cellular_componenttranscription repressor complex
X0019079biological_processviral genome replication
X0019904molecular_functionprotein domain specific binding
X0030154biological_processcell differentiation
X0042802molecular_functionidentical protein binding
X0045892biological_processnegative regulation of DNA-templated transcription
X0045893biological_processpositive regulation of DNA-templated transcription
X0048488biological_processsynaptic vesicle endocytosis
X0050872biological_processwhite fat cell differentiation
X0051287molecular_functionNAD binding
X0051726biological_processregulation of cell cycle
X0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
X0097091biological_processsynaptic vesicle clustering
X0098831cellular_componentpresynaptic active zone cytoplasmic component
X0098978cellular_componentglutamatergic synapse
X0098982cellular_componentGABA-ergic synapse
X0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PROSITE/UniProt
site_idPS00065
Number of Residues28
DetailsD_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD
ChainResidueDetails
ALEU177-ASP204

site_idPS00671
Number of Residues17
DetailsD_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD
ChainResidueDetails
AMET255-ASP271

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AARG266
EGLU295
FARG266
FGLU295
GARG266
GGLU295
HARG266
HGLU295
IARG266
IGLU295
JARG266
AGLU295
JGLU295
KARG266
KGLU295
LARG266
LGLU295
MARG266
MGLU295
NARG266
NGLU295
OARG266
BARG266
OGLU295
PARG266
PGLU295
QARG266
QGLU295
RARG266
RGLU295
SARG266
SGLU295
TARG266
BGLU295
TGLU295
UARG266
UGLU295
VARG266
VGLU295
WARG266
WGLU295
XARG266
XGLU295
CARG266
CGLU295
DARG266
DGLU295
EARG266

site_idSWS_FT_FI2
Number of Residues24
DetailsACT_SITE: Proton donor => ECO:0000250
ChainResidueDetails
AHIS315
JHIS315
KHIS315
LHIS315
MHIS315
NHIS315
OHIS315
PHIS315
QHIS315
RHIS315
SHIS315
BHIS315
THIS315
UHIS315
VHIS315
WHIS315
XHIS315
CHIS315
DHIS315
EHIS315
FHIS315
GHIS315
HHIS315
IHIS315

site_idSWS_FT_FI3
Number of Residues168
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER100
BASP204
OILE180
OASP204
OCYS237
OTHR264
OASP290
OHIS315
PSER100
PILE180
PASP204
PCYS237
BCYS237
PTHR264
PASP290
PHIS315
QSER100
QILE180
QASP204
QCYS237
QTHR264
QASP290
QHIS315
BTHR264
RSER100
RILE180
RASP204
RCYS237
RTHR264
RASP290
RHIS315
SSER100
SILE180
SASP204
BASP290
SCYS237
STHR264
SASP290
SHIS315
TSER100
TILE180
TASP204
TCYS237
TTHR264
TASP290
BHIS315
THIS315
USER100
UILE180
UASP204
UCYS237
UTHR264
UASP290
UHIS315
VSER100
VILE180
CSER100
VASP204
VCYS237
VTHR264
VASP290
VHIS315
WSER100
WILE180
WASP204
WCYS237
WTHR264
CILE180
WASP290
WHIS315
XSER100
XILE180
XASP204
XCYS237
XTHR264
XASP290
XHIS315
CASP204
CCYS237
CTHR264
AILE180
CASP290
CHIS315
DSER100
DILE180
DASP204
DCYS237
DTHR264
DASP290
DHIS315
ESER100
AASP204
EILE180
EASP204
ECYS237
ETHR264
EASP290
EHIS315
FSER100
FILE180
FASP204
FCYS237
ACYS237
FTHR264
FASP290
FHIS315
GSER100
GILE180
GASP204
GCYS237
GTHR264
GASP290
GHIS315
ATHR264
HSER100
HILE180
HASP204
HCYS237
HTHR264
HASP290
HHIS315
ISER100
IILE180
IASP204
AASP290
ICYS237
ITHR264
IASP290
IHIS315
JSER100
JILE180
JASP204
JCYS237
JTHR264
JASP290
AHIS315
JHIS315
KSER100
KILE180
KASP204
KCYS237
KTHR264
KASP290
KHIS315
LSER100
LILE180
BSER100
LASP204
LCYS237
LTHR264
LASP290
LHIS315
MSER100
MILE180
MASP204
MCYS237
MTHR264
BILE180
MASP290
MHIS315
NSER100
NILE180
NASP204
NCYS237
NTHR264
NASP290
NHIS315
OSER100

site_idSWS_FT_FI4
Number of Residues48
DetailsSITE: Cleavage; by CAPN1 => ECO:0000269|PubMed:23707407
ChainResidueDetails
AASN375
EGLY387
FASN375
FGLY387
GASN375
GGLY387
HASN375
HGLY387
IASN375
IGLY387
JASN375
AGLY387
JGLY387
KASN375
KGLY387
LASN375
LGLY387
MASN375
MGLY387
NASN375
NGLY387
OASN375
BASN375
OGLY387
PASN375
PGLY387
QASN375
QGLY387
RASN375
RGLY387
SASN375
SGLY387
TASN375
BGLY387
TGLY387
UASN375
UGLY387
VASN375
VGLY387
WASN375
WGLY387
XASN375
XGLY387
CASN375
CGLY387
DASN375
DGLY387
EASN375

site_idSWS_FT_FI5
Number of Residues24
DetailsSITE: Cleavage; by CAPN1 and CAPN3 => ECO:0000269|PubMed:23707407
ChainResidueDetails
AHIS409
JHIS409
KHIS409
LHIS409
MHIS409
NHIS409
OHIS409
PHIS409
QHIS409
RHIS409
SHIS409
BHIS409
THIS409
UHIS409
VHIS409
WHIS409
XHIS409
CHIS409
DHIS409
EHIS409
FHIS409
GHIS409
HHIS409
IHIS409

site_idSWS_FT_FI6
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER300
JSER300
KSER300
LSER300
MSER300
NSER300
OSER300
PSER300
QSER300
RSER300
SSER300
BSER300
TSER300
USER300
VSER300
WSER300
XSER300
CSER300
DSER300
ESER300
FSER300
GSER300
HSER300
ISER300

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: Phosphoserine; by HIPK2 => ECO:0000269|PubMed:14567915
ChainResidueDetails
ASER422
JSER422
KSER422
LSER422
MSER422
NSER422
OSER422
PSER422
QSER422
RSER422
SSER422
BSER422
TSER422
USER422
VSER422
WSER422
XSER422
CSER422
DSER422
ESER422
FSER422
GSER422
HSER422
ISER422

site_idSWS_FT_FI8
Number of Residues48
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12679040
ChainResidueDetails
ALYS428
FLYS428
GLYS428
HLYS428
ILYS428
JLYS428
KLYS428
LLYS428
MLYS428
NLYS428
OLYS428
BLYS428
PLYS428
QLYS428
RLYS428
SLYS428
TLYS428
ULYS428
VLYS428
WLYS428
XLYS428
CLYS428
DLYS428
ELYS428

224201

PDB entries from 2024-08-28

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