8ANS
Crystal structure of D1228V c-MET bound by compound 1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 296 | 33455.9 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (A) | 3-[bis(fluoranyl)methyl]-~{N}-methyl-~{N}-[(1~{R})-8-methyl-5-(3-methyl-1~{H}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide | non-polymer | 460.5 | 1 | Chemie (MDI) | |||
| 4 | D (A) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 1052 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1051 | - | expression tag |
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33455.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 552.6 | |
| All* | Total formula weight | 34008.5 |
