8ALX

Structure of human PD-L1 in complex with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Programmed cell death 1 ligand 1	polymer	128	14678.8	1	UniProt (Q9NZQ7) Pfam (PF07686)	Homo sapiens (human)	hPD-L1,B7 homolog 1,B7-H1
2	B (B)	3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, AMINOMETHYLAMIDE	polymer	16	1904.2	1		synthetic construct
3	C, E, F (A)	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
4	D, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	H, I (A, B)	water	water		18.0	162	Chemie (HOH)

Sequence modifications

A: 18 - 134 (UniProt: Q9NZQ7)

PDB	External Database	Details
Ala 135	-	expression tag
Ala 136	-	expression tag
Ala 137	-	expression tag
Leu 138	-	expression tag
Glu 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	16583.0
Non-Polymers*	Number of molecules	5
	Total formula weight	361.3
All*	Total formula weight	16944.3

*Water molecules are not included.