8AG1

Crystal structure of a novel OX40 antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (L, l)	Novel OX40 antibody light chain	polymer	216	23610.2	2		Homo sapiens (Human)
2	B, C (H, h)	Novel OX40 antibody heavy chain	polymer	240	26180.1	2		Homo sapiens (Human)
3	E, F (A, a)	Tumor necrosis factor receptor superfamily member 4	polymer	156	17027.0	2	UniProt (P43489) Pfam (PF00020)	Homo sapiens (Human)	ACT35 antigen,OX40L receptor,TAX transcriptionally-activated glycoprotein 1 receptor
4	G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	H, I (L, A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, a: 29 - 170 (UniProt: P43489)

PDB	External Database	Details
Leu 52	Met 52	conflict
Met 171	-	expression tag
Asp 172	-	expression tag
Pro 173	-	expression tag
Gly 174	-	expression tag
Gly 175	-	expression tag
Ser 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	133634.5
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	133855.7

*Water molecules are not included.