8A7E
PAPP-A dimer in complex with its inhibitor STC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | P, A | Stanniocalcin-2 | polymer | 168 | 18923.0 | 2 | UniProt (O76061) Pfam (PF03298) In PDB | Homo sapiens (human) | STC-2,Stanniocalcin-related protein,STC-related protein,STCRP |
| 2 | C, Q | Pappalysin-1 | polymer | 1536 | 171143.0 | 2 | UniProt (Q13219) Pfam (PF13385) Pfam (PF05572) Pfam (PF00084) In PDB | Homo sapiens (human) | Insulin-like growth factor-dependent IGF-binding protein 4 protease,IGF-dependent IGFBP-4 protease,IGFBP-4ase,Pregnancy-associated plasma protein A,PAPP-A |
| 3 | C, Q | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | C, Q | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) |
Sequence modifications
C, Q: 82 - 1617 (UniProt: Q13219)
| PDB | External Database | Details |
|---|---|---|
| Gln 563 | Glu 563 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 380132.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 772.1 | |
| All* | Total formula weight | 380904.1 |
