8A7E

PAPP-A dimer in complex with its inhibitor STC2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
C	0004175	molecular_function	endopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007565	biological_process	female pregnancy
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0030163	biological_process	protein catabolic process
C	0032354	biological_process	response to follicle-stimulating hormone
C	0046872	molecular_function	metal ion binding
C	0071548	biological_process	response to dexamethasone
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region
Q	0004175	molecular_function	endopeptidase activity
Q	0004222	molecular_function	metalloendopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0006508	biological_process	proteolysis
Q	0007166	biological_process	cell surface receptor signaling pathway
Q	0007565	biological_process	female pregnancy
Q	0008237	molecular_function	metallopeptidase activity
Q	0008270	molecular_function	zinc ion binding
Q	0030163	biological_process	protein catabolic process
Q	0032354	biological_process	response to follicle-stimulating hormone
Q	0046872	molecular_function	metal ion binding
Q	0071548	biological_process	response to dexamethasone

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
C	GLN563
Q	GLN563

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
C	HIS562
C	HIS566
C	HIS572
Q	HIS562
Q	HIS566
Q	HIS572

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN390
C	ASN825
C	ASN1222
C	ASN1465
Q	ASN390
Q	ASN825
Q	ASN1222
Q	ASN1465

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12421832

Chain	Residue	Details
C	ASN402
C	ASN1519
Q	ASN402
Q	ASN429
Q	ASN480
Q	ASN601
Q	ASN619
Q	ASN725
Q	ASN1026
Q	ASN1226
Q	ASN1323
C	ASN429
Q	ASN1519
C	ASN480
C	ASN601
C	ASN619
C	ASN725
C	ASN1026
C	ASN1226
C	ASN1323

---