7ZWL
Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Stimulator of interferon protein | polymer | 204 | 23189.1 | 2 | UniProt (A0A2R3XZB7) Pfam (PF15009) UniProt (by SIFTS) (Q86WV6) | Homo sapiens (human) | |
| 2 | C (C) | Ubiquitin-like protein SMT3 | polymer | 98 | 11204.5 | 1 | UniProt (Q12306) Pfam (PF00240) | Saccharomyces cerevisiae (baker's yeast) | |
| 3 | D (A) | 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine | non-polymer | 658.4 | 1 | Chemie (K43) | |||
| 4 | E, F, G (A, B, C) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
C: 2 - 98 (UniProt: Q12306)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57582.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 658.4 | |
| All* | Total formula weight | 58241.1 |
