7ZWA

CryoEM structure of Ku heterodimer bound to DNA and PAXX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	X-ray repair cross-complementing protein 6	polymer	609	69945.0	1	UniProt (P12956) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF02037)	Homo sapiens (human)	5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
2	B (B)	X-ray repair cross-complementing protein 5	polymer	732	82812.4	1	UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785)	Homo sapiens (human)	86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
3	C (C)	Protein PAXX	polymer	204	21663.5	1	UniProt (Q9BUH6) Pfam (PF15384)	Homo sapiens (human)	Paralog of XRCC4 and XLF,XRCC4-like small protein
4	D (D)	DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3')	polymer	15	4544.0	1		Homo sapiens
5	E (E)	DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3')	polymer	16	4962.2	1		Homo sapiens
6	F (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	183927.2
Non-Polymers*	Number of molecules	1
	Total formula weight	95.0
All*	Total formula weight	184022.2

*Water molecules are not included.