7ZTL
Crystal structure of a covalently linked Aurora-A N-Myc complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 309 | 35943.9 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B (B) | N-myc proto-oncogene protein | polymer | 62 | 7105.8 | 1 | UniProt (P04198) | Homo sapiens | Class E basic helix-loop-helix protein 37,bHLHe37 |
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G, I (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | H (A) | BICINE | non-polymer | 163.2 | 1 | Chemie (BCN) | |||
| 7 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | K (B) | 4-(3-hydroxy-3-oxopropylamino)-4-oxidanylidene-butanoic acid | non-polymer | 189.2 | 1 | Chemie (JWG) | |||
| 9 | L, M (A, B) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
B: 28 - 89 (UniProt: P04198)
| PDB | External Database | Details |
|---|---|---|
| Met 95 | - | initiating methionine |
| Lys 96 | - | expression tag |
| His 97 | - | expression tag |
| His 98 | - | expression tag |
| His 99 | - | expression tag |
| His 100 | - | expression tag |
| His 101 | - | expression tag |
| His 102 | - | expression tag |
| Pro 103 | - | expression tag |
| Met 104 | - | expression tag |
| Ser 105 | - | expression tag |
| Asp 106 | - | expression tag |
| Tyr 107 | - | expression tag |
| Asp 108 | - | expression tag |
| Ile 109 | - | expression tag |
| Pro 110 | - | expression tag |
| Thr 111 | - | expression tag |
| Thr 112 | - | expression tag |
| Glu 113 | - | expression tag |
| Asn 114 | - | expression tag |
| Leu 115 | - | expression tag |
| Tyr 116 | - | expression tag |
| Phe 117 | - | expression tag |
| Gln 118 | - | expression tag |
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
| Ala 290 | Cys 290 | engineered mutation |
| Cys 339 | Lys 339 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 85 | Asn 85 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43049.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1127.4 | |
| All* | Total formula weight | 44177.1 |
