7ZTL
Crystal structure of a covalently linked Aurora-A N-Myc complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase A | polymer | 309 | 35943.9 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
2 | B | N-myc proto-oncogene protein | polymer | 62 | 7105.8 | 1 | UniProt (P04198) In PDB | Homo sapiens | Class E basic helix-loop-helix protein 37,bHLHe37 |
3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
6 | A | BICINE | non-polymer | 163.2 | 1 | Chemie (BCN) | |||
7 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
8 | B | 4-(3-hydroxy-3-oxopropylamino)-4-oxidanylidene-butanoic acid | non-polymer | 189.2 | 1 | Chemie (JWG) | |||
9 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
B: 28 - 89 (UniProt: P04198)
PDB | External Database | Details |
---|---|---|
Met 95 | - | initiating methionine |
Lys 96 | - | expression tag |
His 97 | - | expression tag |
His 98 | - | expression tag |
His 99 | - | expression tag |
His 100 | - | expression tag |
His 101 | - | expression tag |
His 102 | - | expression tag |
Pro 103 | - | expression tag |
Met 104 | - | expression tag |
Ser 105 | - | expression tag |
Asp 106 | - | expression tag |
Tyr 107 | - | expression tag |
Asp 108 | - | expression tag |
Ile 109 | - | expression tag |
Pro 110 | - | expression tag |
Thr 111 | - | expression tag |
Thr 112 | - | expression tag |
Glu 113 | - | expression tag |
Asn 114 | - | expression tag |
Leu 115 | - | expression tag |
Tyr 116 | - | expression tag |
Phe 117 | - | expression tag |
Gln 118 | - | expression tag |
Gly 119 | - | expression tag |
Ala 120 | - | expression tag |
Met 121 | - | expression tag |
Ala 290 | Cys 290 | engineered mutation |
Cys 339 | Lys 339 | engineered mutation |
Ala 393 | Cys 393 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 85 | Asn 85 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43049.7 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1127.4 | |
All* | Total formula weight | 44177.1 |