7ZT2

Structure of E8 TCR in complex with human MR1 bound to 5-OP-RU

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Major histocompatibility complex class I-related gene protein	polymer	290	33782.9	1	UniProt (Q95460) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	MHC class I-related gene protein,Class I histocompatibility antigen-like protein
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C (D)	E8 TCR Alpha	polymer	205	22884.4	1		Homo sapiens
4	D (E)	E8 TCR beta	polymer	262	29243.3	1		Homo sapiens
5	E (A)	1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol	non-polymer		316.3	1	Chemie (2LJ)
6	F, G (A, E)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	H, I, J, K (A, B, D, E)	water	water		18.0	55	Chemie (HOH)

Sequence modifications

A: 1 - 270 (UniProt: Q95460)

PDB	External Database	Details
Met 0	-	initiating methionine
Ser 261	Cys 283	conflict
Gly 271	-	expression tag
Ser 272	-	expression tag
Gly 273	-	expression tag
Gly 274	-	expression tag
Gly 275	-	expression tag
Leu 276	-	expression tag
Asn 277	-	expression tag
Asp 278	-	expression tag
Ile 279	-	expression tag
Phe 280	-	expression tag
Glu 281	-	expression tag
Ala 282	-	expression tag
Gln 283	-	expression tag
Lys 284	-	expression tag
Ile 285	-	expression tag
Glu 286	-	expression tag
Trp 287	-	expression tag
His 288	-	expression tag
Glu 289	-	expression tag

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	97789.9
Non-Polymers*	Number of molecules	3
	Total formula weight	440.4
All*	Total formula weight	98230.3

*Water molecules are not included.