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7ZR5

CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BHeat shock protein HSP 90-betapolymer74986223.52UniProt (P08238)
Pfam (PF13589)
Pfam (PF00183)
In PDB
Homo sapiens (human)HSP 90,Heat shock 84 kDa,HSP 84,HSP84
2CHsp90 co-chaperone Cdc37polymer39646853.81UniProt (Q16543)
Pfam (PF03234)
Pfam (PF08565)
Pfam (PF08564)
In PDB
Homo sapiens (human)Hsp90 chaperone protein kinase-targeting subunit,p50Cdc37
3KSerine/threonine-protein kinase B-rafpolymer82890934.51UniProt (P15056)
Pfam (PF02196)
Pfam (PF00130)
Pfam (PF07714)
In PDB
Homo sapiens (human)Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
4PSerine/threonine-protein phosphatase 5polymer48956020.41UniProt (P53041)
Pfam (PF08321)
Pfam (PF00149)
Pfam (PF00515)
In PDB
Homo sapiens (human)PP5,Protein phosphatase T,PP-T,PPT
5A, BADENOSINE-5'-TRIPHOSPHATEnon-polymer507.22Chemie (ATP)
Sequence modifications
A, B: 1 - 724 (UniProt: P08238)
PDBExternal DatabaseDetails
Met -24-initiating methionine
Arg -23-expression tag
Gly -22-expression tag
Ser -21-expression tag
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
Gly -12-expression tag
Met -11-expression tag
Ala -10-expression tag
Leu -9-expression tag
Glu -8-expression tag
Val -7-expression tag
Leu -6-expression tag
Phe -5-expression tag
Gln -4-expression tag
Gly -3-expression tag
Pro -2-expression tag
Ser -1-expression tag
Ala 0-expression tag
C: 1 - 378 (UniProt: Q16543)
PDBExternal DatabaseDetails
Leu 379-expression tag
Glu 380-expression tag
Val 381-expression tag
Leu 382-expression tag
Phe 383-expression tag
Gln 384-expression tag
Gly 385-expression tag
Pro 386-expression tag
Leu 387-expression tag
Glu 388-expression tag
His 389-expression tag
His 390-expression tag
His 391-expression tag
His 392-expression tag
His 393-expression tag
His 394-expression tag
His 395-expression tag
His 396-expression tag
K: 1 - 766 (UniProt: P15056)
PDBExternal DatabaseDetails
Met -61-initiating methionine
Gly -60-expression tag
Gly -59-expression tag
Ser -58-expression tag
His -57-expression tag
His -56-expression tag
His -55-expression tag
His -54-expression tag
His -53-expression tag
His -52-expression tag
His -51-expression tag
His -50-expression tag
Gly -49-expression tag
Gly -48-expression tag
Ser -47-expression tag
Trp -46-expression tag
Ser -45-expression tag
His -44-expression tag
Pro -43-expression tag
Gln -42-expression tag
Phe -41-expression tag
Glu -40-expression tag
Lys -39-expression tag
Gly -38-expression tag
Gly -37-expression tag
Gly -36-expression tag
Ser -35-expression tag
Gly -34-expression tag
Gly -33-expression tag
Gly -32-expression tag
Ser -31-expression tag
Gly -30-expression tag
Gly -29-expression tag
Gly -28-expression tag
Ser -27-expression tag
Trp -26-expression tag
Ser -25-expression tag
His -24-expression tag
Pro -23-expression tag
Gln -22-expression tag
Phe -21-expression tag
Glu -20-expression tag
Lys -19-expression tag
Gly -18-expression tag
Ala -17-expression tag
Glu -16-expression tag
Thr -15-expression tag
Ala -14-expression tag
Val -13-expression tag
Pro -12-expression tag
Asn -11-expression tag
Ser -10-expression tag
Leu -9-expression tag
Glu -8-expression tag
Val -7-expression tag
Leu -6-expression tag
Phe -5-expression tag
Gln -4-expression tag
Gly -3-expression tag
Pro -2-expression tag
Ser -1-expression tag
Ala 0-expression tag
Glu 600Val 600variant
P: 17 - 499 (UniProt: P53041)
PDBExternal DatabaseDetails
His 500-expression tag
His 501-expression tag
His 502-expression tag
His 503-expression tag
His 504-expression tag
His 505-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight366255.6
Non-Polymers*Number of molecules2
Total formula weight1014.4
All*Total formula weight367270.0
*Water molecules are not included.

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PDB entries from 2024-06-12

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