7ZOC
Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl-2-alkylmercaptoacetamide-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Collagenase ColH | polymer | 413 | 48094.1 | 1 | UniProt (Q46085) | Hathewaya histolytica | Class II collagenase,Gelatinase ColH,Microbial collagenase |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | ~{N}-(4-ethanoylphenyl)-2-sulfanyl-propanamide | non-polymer | 223.3 | 1 | Chemie (T8E) | |||
| 5 | E (A) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A: 331 - 721 (UniProt: Q46085)
| PDB | External Database | Details |
|---|---|---|
| Met 309 | - | initiating methionine |
| Gly 310 | - | expression tag |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| His 318 | - | expression tag |
| Ser 319 | - | expression tag |
| Ser 320 | - | expression tag |
| Gly 321 | - | expression tag |
| Glu 322 | - | expression tag |
| Asn 323 | - | expression tag |
| Leu 324 | - | expression tag |
| Tyr 325 | - | expression tag |
| Phe 326 | - | expression tag |
| Gln 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Gly 329 | - | expression tag |
| Thr 330 | - | expression tag |
| His 582 | Tyr 582 | conflict |
| Val 659 | Ala 659 | conflict |
| Lys 706 | Arg 706 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48094.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 328.8 | |
| All* | Total formula weight | 48422.9 |
